First Nosocomial Outbreak of Pseudomonas Aeruginosa Producing an Integron-borne Metallo-beta-lactamase (VIM-2) in the United States

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2005 Jul 29

PMID 16048978

Citations 55

Authors

K Lolans

A M Queenan

K Bush

A Sahud

J P Quinn

Affiliations

Soon will be listed here.

Abstract

Carbapenemases are rare in the United States. This is the first report of a United States nosocomial outbreak of pan-resistant Pseudomonas aeruginosa infections due to an integron-borne metallo-beta-lactamase, VIM-2. This emergence of carbapenemases on mobile genetic elements in the United States warrants surveillance.

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References

Cornaglia G, Mazzariol A, Lauretti L, Rossolini G, Fontana R . Hospital outbreak of carbapenem-resistant Pseudomonas aeruginosa producing VIM-1, a novel transferable metallo-beta-lactamase. Clin Infect Dis. 2000; 31(5):1119-25. DOI: 10.1086/317448. View

Poirel L, Naas T, Nicolas D, Collet L, Bellais S, Cavallo J . Characterization of VIM-2, a carbapenem-hydrolyzing metallo-beta-lactamase and its plasmid- and integron-borne gene from a Pseudomonas aeruginosa clinical isolate in France. Antimicrob Agents Chemother. 2000; 44(4):891-7. PMC: 89788. DOI: 10.1128/AAC.44.4.891-897.2000. View

Gibb A, Tribuddharat C, Moore R, Louie T, Krulicki W, Livermore D . Nosocomial outbreak of carbapenem-resistant Pseudomonas aeruginosa with a new bla(IMP) allele, bla(IMP-7). Antimicrob Agents Chemother. 2001; 46(1):255-8. PMC: 126979. DOI: 10.1128/AAC.46.1.255-258.2002. View

Bellais S, Mimoz O, Leotard S, Jacolot A, Petitjean O, Nordmann P . Efficacy of beta-lactams for treating experimentally induced pneumonia due to a carbapenem-hydrolyzing metallo-beta-lactamase-producing strain of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2002; 46(6):2032-4. PMC: 127240. DOI: 10.1128/AAC.46.6.2032-2034.2002. View

Poirel L, Nordmann P . Acquired carbapenem-hydrolyzing beta-lactamases and their genetic support. Curr Pharm Biotechnol. 2002; 3(2):117-27. DOI: 10.2174/1389201023378427. View

Nordmann P, Poirel L . Emerging carbapenemases in Gram-negative aerobes. Clin Microbiol Infect. 2002; 8(6):321-31. DOI: 10.1046/j.1469-0691.2002.00401.x. View

Walsh T, Bolmstrom A, Qwarnstrom A, Gales A . Evaluation of a new Etest for detecting metallo-beta-lactamases in routine clinical testing. J Clin Microbiol. 2002; 40(8):2755-9. PMC: 120685. DOI: 10.1128/JCM.40.8.2755-2759.2002. View

Toleman M, Simm A, Murphy T, Gales A, Biedenbach D, Jones R . Molecular characterization of SPM-1, a novel metallo-beta-lactamase isolated in Latin America: report from the SENTRY antimicrobial surveillance programme. J Antimicrob Chemother. 2002; 50(5):673-9. DOI: 10.1093/jac/dkf210. View

Pournaras S, Maniati M, Petinaki E, Tzouvelekis L, Tsakris A, Legakis N . Hospital outbreak of multiple clones of Pseudomonas aeruginosa carrying the unrelated metallo-beta-lactamase gene variants blaVIM-2 and blaVIM-4. J Antimicrob Chemother. 2003; 51(6):1409-14. DOI: 10.1093/jac/dkg239. View

10.

Livermore D, Sefton A, Scott G . Properties and potential of ertapenem. J Antimicrob Chemother. 2003; 52(3):331-44. DOI: 10.1093/jac/dkg375. View

11.

Lee K, Lim Y, Yong D, Yum J, Chong Y . Evaluation of the Hodge test and the imipenem-EDTA double-disk synergy test for differentiating metallo-beta-lactamase-producing isolates of Pseudomonas spp. and Acinetobacter spp. J Clin Microbiol. 2003; 41(10):4623-9. PMC: 254300. DOI: 10.1128/JCM.41.10.4623-4629.2003. View

12.

Toleman M, Rolston K, Jones R, Walsh T . blaVIM-7, an evolutionarily distinct metallo-beta-lactamase gene in a Pseudomonas aeruginosa isolate from the United States. Antimicrob Agents Chemother. 2003; 48(1):329-32. PMC: 310168. DOI: 10.1128/AAC.48.1.329-332.2004. View

13.

Mathew A, Harris A, Marshall M, Ross G . The use of analytical isoelectric focusing for detection and identification of beta-lactamases. J Gen Microbiol. 1975; 88(1):169-78. DOI: 10.1099/00221287-88-1-169. View

14.

Sykes R, Bonner D, Bush K, Georgopapadakou N . Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria. Antimicrob Agents Chemother. 1982; 21(1):85-92. PMC: 181833. DOI: 10.1128/AAC.21.1.85. View

15.

Sanders C, Sanders Jr W, Moland E . Characterization of beta-lactamases in situ on polyacrylamide gels. Antimicrob Agents Chemother. 1986; 30(6):951-2. PMC: 180628. DOI: 10.1128/AAC.30.6.951. View

16.

Radstrom P, SKOLD O, Swedberg G, Flensburg J, Roy P, Sundstrom L . Transposon Tn5090 of plasmid R751, which carries an integron, is related to Tn7, Mu, and the retroelements. J Bacteriol. 1994; 176(11):3257-68. PMC: 205496. DOI: 10.1128/jb.176.11.3257-3268.1994. View

17.

Bush K, Jacoby G, Medeiros A . A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrob Agents Chemother. 1995; 39(6):1211-33. PMC: 162717. DOI: 10.1128/AAC.39.6.1211. View

18.

Senda K, Arakawa Y, Nakashima K, Ito H, Ichiyama S, Shimokata K . Multifocal outbreaks of metallo-beta-lactamase-producing Pseudomonas aeruginosa resistant to broad-spectrum beta-lactams, including carbapenems. Antimicrob Agents Chemother. 1996; 40(2):349-53. PMC: 163114. DOI: 10.1128/AAC.40.2.349. View

19.

Matushek M, Bonten M, Hayden M . Rapid preparation of bacterial DNA for pulsed-field gel electrophoresis. J Clin Microbiol. 1996; 34(10):2598-600. PMC: 229328. DOI: 10.1128/jcm.34.10.2598-2600.1996. View

20.

Rasmussen B, Bush K . Carbapenem-hydrolyzing beta-lactamases. Antimicrob Agents Chemother. 1997; 41(2):223-32. PMC: 163693. DOI: 10.1128/AAC.41.2.223. View