Coproduction of KPC-18 and VIM-1 Carbapenemases by Enterobacter Cloacae: Implications for Newer β-Lactam-β-Lactamase Inhibitor Combinations

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 2016 Jan 1

PMID 26719440

Citations 8

Authors

Gina K Thomson

James W Snyder

Christi L McElheny

Kenneth S Thomson

Yohei Doi

Affiliations

Soon will be listed here.

Abstract

Enterobacter cloacae strain G6809 with reduced susceptibility to carbapenems was identified from a patient in a long-term acute care hospital in Kentucky. G6809 belonged to sequence type (ST) 88 and carried two carbapenemase genes, bla(KPC-18) and bla(VIM-1). Whole-genome sequencing localized bla(KPC-18) to the chromosome and bla(VIM-1) to a 58-kb plasmid. The strain was highly resistant to ceftazidime-avibactam. Insidious coproduction of metallo-β-lactamase with KPC-type carbapenemase has implications for the use of next-generation β-lactam-β-lactamase inhibitor combinations.

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