Prevalence of Clinically Isolated Metallo-beta-lactamase-producing , Coding Genes, and Possible Risk Factors in Iran

Overview

Journal Iran J Pathol

Date 2018 May 8

PMID 29731790

Citations 8

Authors

Abdolmajid Ghasemian

Kobra Salimian Rizi

Hassan Rajabi Vardanjani

Farshad Nojoomi

Affiliations

Soon will be listed here.

Abstract

Background & Objective: The spread of carbapenem-resistant is a global concern. Metallo-beta-lactamase (MBL) enzymes cause extensive drug resistance among Gram-negative bacteria. The current study aimed at determining the prevalence of MBL-producing in Iran.

Data Extraction: A total of 43 studies were found out of which 36 were adopted. Data were collected from Google, Google Scholar, Science Direct, PubMed, Scopus, Embase, and Sciverse. The terms "", "metallo-beta-lactamase", "prevalence", "carbapenems", and "Iran" were searched. Data from the isolates not producing MBLs were excluded from the study. Data were analyzed with Graph Pad Prism 6, meta-analysis section.

Results: According to the results of the current study, 36 surveys indicated that 55% of the clinically isolated in Iran were resistant to imipenem and meropenem, among which 37.72% were the MBL producers. Among genes encoding MBLs, and were predominant with the prevalence of 12.91%±11.01% and 12.50%±23.56%, respectively. No report of harboring and bla by was found, similar to most of the other countries in Asia. The prevalence of and from burn settings were 11.50%±3.5% and 24.65%±23%, respectively. Furthermore, the prevalence of these genes was not significantly different among burn and non-burn isolates (P=0.942 and P=0.597, respectively). Moreover, no relationship was observed between the MBL production and patients' age range.

Conclusion: Approximately half of isolates were carbapenem-resistant in Iran, and approximately half were the MBL producers. The and were the predominant MBLs among . strains, while other genes were not found in . Moreover, there was no significant difference between and among burn and non-burn isolates. Due to the multiple drug resistance conferred by MBLs, detection and control of their spread alongside proper therapeutic regimens in hospitals and community settings are essential to prevent infection acquisition.

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