The DNA-polymerase-X Family: Controllers of DNA Quality?

Overview

Journal Nat Rev Mol Cell Biol

Specialties Cell Biology
Molecular Biology

Date 2004 Dec 2

PMID 15573140

Citations 40

Authors

Kristijan Ramadan

Igor Shevelev

Ulrich Hubscher

Affiliations

Soon will be listed here.

Abstract

Synthesis of the genetic material of the cell is achieved by a large number of DNA polymerases. Besides replicating the genome, they are involved in DNA-repair processes. Recent studies have indicated that certain DNA-polymerase-X-family members can synthesize unusual DNA structures, and we propose that these DNA structures might serve as 'flag wavers' for the induction of DNA-repair and/or DNA-damage-checkpoint pathways.

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