Molecular Mediators of Hepatic Steatosis and Liver Injury

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2004 Jul 16

PMID 15254578

Citations 789

Authors

Jeffrey D Browning

Jay D Horton

Affiliations

Soon will be listed here.

Abstract

Obesity and its associated comorbidities are among the most prevalent and challenging conditions confronting the medical profession in the 21st century. A major metabolic consequence of obesity is insulin resistance, which is strongly associated with the deposition of triglycerides in the liver. Hepatic steatosis can either be a benign, noninflammatory condition that appears to have no adverse sequelae or can be associated with steatohepatitis: a condition that can result in end-stage liver disease, accounting for up to 14% of liver transplants in the US. Here we highlight recent advances in our understanding of the molecular events contributing to hepatic steatosis and nonalcoholic steatohepatitis.

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