Helicobacter Pylori Persistence: Biology and Disease

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2004 Feb 3

PMID 14755326

Citations 350

Authors

Martin J Blaser

John C Atherton

Affiliations

Soon will be listed here.

Abstract

Helicobacter pylori are bacteria that have coevolved with humans to be transmitted from person to person and to persistently colonize the stomach. Their population structure is a model for the ecology of the indigenous microbiota. A well-choreographed equilibrium between bacterial effectors and host responses permits microbial persistence and health of the host but confers risk of serious diseases, including peptic ulceration and gastric neoplasia.

Citing Articles

infection and staple-line leak in patients with class III obesity undergoing laparoscopic sleeve gastrectomy: a retrospective study.

Kazim A, Bamehriz F, Althwanay A, Aldohayan A, Abdullah A, Alshehri B BMJ Open Gastroenterol. 2025; 11(1.

PMID: 39797659 PMC: 11664374. DOI: 10.1136/bmjgast-2024-001622.

The role of cuproptosis in gastric cancer.

Li Y, Sun W, Yuan S, Liu X, Zhang Z, Gu R Front Immunol. 2024; 15:1435651.

PMID: 39539553 PMC: 11558255. DOI: 10.3389/fimmu.2024.1435651.

Key characteristics of carcinogens meet hallmarks for prevention-cutting the Gordian knot.

Senga S, Bisson W, Colacci A Front Oncol. 2024; 14:1420687.

PMID: 39435286 PMC: 11491790. DOI: 10.3389/fonc.2024.1420687.

Bacterial small molecule metabolites implicated in gastrointestinal cancer development.

Turocy T, Crawford J Nat Rev Microbiol. 2024; 23(2):106-121.

PMID: 39375475 DOI: 10.1038/s41579-024-01103-4.

Association between infection with Helicobacter pylori and metabolic syndrome among diabetic patients attending Jimma medical center in Jimma city, Ethiopia: a cross-sectional study.

Ibrahim T, Russel W, Getachew A, Zemene E, Cheneke W, Taye B BMC Infect Dis. 2024; 24(1):922.

PMID: 39237908 PMC: 11378407. DOI: 10.1186/s12879-024-09840-w.

References

Bamford K, Fan X, Crowe S, Leary J, Gourley W, Luthra G . Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology. 1998; 114(3):482-92. DOI: 10.1016/s0016-5085(98)70531-1. View

LEDERBERG J . Infectious history. Science. 2000; 288(5464):287-93. DOI: 10.1126/science.288.5464.287. View

Aras R, Kang J, Tschumi A, Harasaki Y, Blaser M . Extensive repetitive DNA facilitates prokaryotic genome plasticity. Proc Natl Acad Sci U S A. 2003; 100(23):13579-84. PMC: 263856. DOI: 10.1073/pnas.1735481100. View

Maeda S, Akanuma M, Mitsuno Y, Hirata Y, Ogura K, Yoshida H . Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells. J Biol Chem. 2001; 276(48):44856-64. DOI: 10.1074/jbc.M105381200. View

Wagner S, Beil W, Westermann J, Logan R, Bock C, Trautwein C . Regulation of gastric epithelial cell growth by Helicobacter pylori: offdence for a major role of apoptosis. Gastroenterology. 1997; 113(6):1836-47. DOI: 10.1016/s0016-5085(97)70003-9. View

Wang G, Ge Z, Rasko D, Taylor D . Lewis antigens in Helicobacter pylori: biosynthesis and phase variation. Mol Microbiol. 2000; 36(6):1187-96. DOI: 10.1046/j.1365-2958.2000.01934.x. View

Mohammadi M, Nedrud J, Redline R, Lycke N, Czinn S . Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load. Gastroenterology. 1997; 113(6):1848-57. DOI: 10.1016/s0016-5085(97)70004-0. View

Parsonnet J . The incidence of Helicobacter pylori infection. Aliment Pharmacol Ther. 1995; 9 Suppl 2:45-51. View

Blaser M, Berg D . Helicobacter pylori genetic diversity and risk of human disease. J Clin Invest. 2001; 107(7):767-73. PMC: 199587. DOI: 10.1172/JCI12672. View

10.

Rothenbacher D, Blaser M, Bode G, Brenner H . Inverse relationship between gastric colonization of Helicobacter pylori and diarrheal illnesses in children: results of a population-based cross-sectional study. J Infect Dis. 2000; 182(5):1446-9. DOI: 10.1086/315887. View

11.

Rudi J, Kuck D, Strand S, von Herbay A, Mariani S, Krammer P . Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest. 1998; 102(8):1506-14. PMC: 509000. DOI: 10.1172/JCI2808. View

12.

El-Omar E, Penman I, Ardill J, Chittajallu R, Howie C, McColl K . Helicobacter pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology. 1995; 109(3):681-91. DOI: 10.1016/0016-5085(95)90374-7. View

13.

Falush D, Wirth T, Linz B, Pritchard J, Stephens M, Kidd M . Traces of human migrations in Helicobacter pylori populations. Science. 2003; 299(5612):1582-5. DOI: 10.1126/science.1080857. View

14.

Suerbaum S, Smith J, Bapumia K, Morelli G, Smith N, Kunstmann E . Free recombination within Helicobacter pylori. Proc Natl Acad Sci U S A. 1998; 95(21):12619-24. PMC: 22880. DOI: 10.1073/pnas.95.21.12619. View

15.

Gebert B, Fischer W, Weiss E, Hoffmann R, Haas R . Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science. 2003; 301(5636):1099-102. DOI: 10.1126/science.1086871. View

16.

Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N . Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology. 2001; 120(2):337-45. DOI: 10.1053/gast.2001.22158. View

17.

Khulusi S, Badve S, Patel P, Lloyd R, Marrero J, Finlayson C . Pathogenesis of gastric metaplasia of the human duodenum: role of Helicobacter pylori, gastric acid, and ulceration. Gastroenterology. 1996; 110(2):452-8. DOI: 10.1053/gast.1996.v110.pm8566592. View

18.

Cover T, Krishna U, Israel D, Peek Jr R . Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res. 2003; 63(5):951-7. View

19.

Fan X, Crowe S, Behar S, Gunasena H, Ye G, Haeberle H . The effect of class II major histocompatibility complex expression on adherence of Helicobacter pylori and induction of apoptosis in gastric epithelial cells: a mechanism for T helper cell type 1-mediated damage. J Exp Med. 1998; 187(10):1659-69. PMC: 2212295. DOI: 10.1084/jem.187.10.1659. View

20.

Peek Jr R, Blaser M . Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nat Rev Cancer. 2002; 2(1):28-37. DOI: 10.1038/nrc703. View