IgY Antibodies: The Promising Potential to Overcome Antibiotic Resistance

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Feb 6

PMID 36742328

Authors

Sherif A El-Kafrawy

Aymn T Abbas

Christopher Oelkrug

Marwa Tahoon

Sameera Ezzat

Alimuddin Zumla

Esam I Azhar

Affiliations

Soon will be listed here.

Abstract

Antibiotic resistant bacteria are a growing threat to global health security. Whilst the emergence of antimicrobial resistance (AMR) is a natural phenomenon, it is also driven by antibiotic exposure in health care, agriculture, and the environment. Antibiotic pressure and inappropriate use of antibiotics are important factors which drive resistance. Apart from their use to treat bacterial infections in humans, antibiotics also play an important role in animal husbandry. With limited antibiotic options, alternate strategies are required to overcome AMR. Passive immunization through oral, nasal and topical administration of egg yolk-derived IgY antibodies from immunized chickens were recently shown to be effective for treating bacterial infections in animals and humans. Immunization of chickens with specific antigens offers the possibility of creating specific antibodies targeting a wide range of antibiotic-resistant bacteria. In this review, we describe the growing global problem of antimicrobial resistance and highlight the promising potential of the use of egg yolk IgY antibodies for the treatment of bacterial infections, particularly those listed in the World Health Organization priority list.

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References

Carlander D, Kollberg H, Wejaker P, Larsson A . Peroral immunotherapy with yolk antibodies for the prevention and treatment of enteric infections. Immunol Res. 2000; 21(1):1-6. PMC: 7090601. DOI: 10.1385/ir:21:1:1. View

Terzolo H, Sandoval V, Caffer M, Terragno R, Alcain A . [Agglutination of hen egg-yolk immunoglobulins (IgY) against Salmonella enterica, serovar enteritidis]. Rev Argent Microbiol. 1998; 30(2):84-92. View

Schade R, Calzado E, Sarmiento R, Chacana P, Porankiewicz-Asplund J, Terzolo H . Chicken egg yolk antibodies (IgY-technology): a review of progress in production and use in research and human and veterinary medicine. Altern Lab Anim. 2005; 33(2):129-54. DOI: 10.1177/026119290503300208. View

Martinez J, Baquero F . Mutation frequencies and antibiotic resistance. Antimicrob Agents Chemother. 2000; 44(7):1771-7. PMC: 89960. DOI: 10.1128/AAC.44.7.1771-1777.2000. View

Nomura S, Suzuki H, Masaoka T, Kurabayashi K, Ishii H, Kitajima M . Effect of dietary anti-urease immunoglobulin Y on Helicobacter pylori infection in Mongolian gerbils. Helicobacter. 2005; 10(1):43-52. DOI: 10.1111/j.1523-5378.2005.00290.x. View

Lee W, Syed Atif A, Tan S, Leow C . Insights into the chicken IgY with emphasis on the generation and applications of chicken recombinant monoclonal antibodies. J Immunol Methods. 2017; 447:71-85. DOI: 10.1016/j.jim.2017.05.001. View

Gygli S, Borrell S, Trauner A, Gagneux S . Antimicrobial resistance in Mycobacterium tuberculosis: mechanistic and evolutionary perspectives. FEMS Microbiol Rev. 2017; 41(3):354-373. DOI: 10.1093/femsre/fux011. View

Shin J, Yang M, Nam S, Kim J, Myung N, Bang W . Use of egg yolk-derived immunoglobulin as an alternative to antibiotic treatment for control of Helicobacter pylori infection. Clin Diagn Lab Immunol. 2002; 9(5):1061-6. PMC: 120060. DOI: 10.1128/cdli.9.5.1061-1066.2002. View

Luo G, Spellberg B, Gebremariam T, Bolaris M, Lee H, Fu Y . Diabetic murine models for Acinetobacter baumannii infection. J Antimicrob Chemother. 2012; 67(6):1439-45. PMC: 3584961. DOI: 10.1093/jac/dks050. View

10.

Schuller Y, Biegstraaten M, Hollak C, Klumpen H, Gispen-de Wied C, Stoyanova-Beninska V . Oncologic orphan drugs approved in the EU - do clinical trial data correspond with real-world effectiveness?. Orphanet J Rare Dis. 2018; 13(1):214. PMC: 6263065. DOI: 10.1186/s13023-018-0900-9. View

11.

ODonnell K, Meberg B, Schiltz J, Nilles M, Bradley D . Zika Virus-Specific IgY Results Are Therapeutic Following a Lethal Zika Virus Challenge without Inducing Antibody-Dependent Enhancement. Viruses. 2019; 11(3). PMC: 6466411. DOI: 10.3390/v11030301. View

12.

Leiva C, Geoghegan P, Lammer M, Cangelosi A, Mariconda V, Celi A . In vivo neutralization of bee venom lethality by IgY antibodies. Mol Immunol. 2021; 135:183-190. DOI: 10.1016/j.molimm.2021.04.015. View

13.

Aiba Y, Umeda K, Rahman S, Nguyen S, Komatsu Y . Synergistic effect of anti-Helicobacter pylori urease immunoglobulin Y from egg yolk of immunized hens and Lactobacillus johnsonii No.1088 to inhibit the growth of Helicobacter pylori in vitro and in vivo. Vaccine. 2019; 37(23):3106-3112. DOI: 10.1016/j.vaccine.2019.04.045. View

14.

Thomsen K, Christophersen L, Bjarnsholt T, Jensen P, Moser C, Hoiby N . Anti-Pseudomonas aeruginosa IgY Antibodies Induce Specific Bacterial Aggregation and Internalization in Human Polymorphonuclear Neutrophils. Infect Immun. 2015; 83(7):2686-93. PMC: 4468541. DOI: 10.1128/IAI.02970-14. View

15.

Hegstad K, Mikalsen T, Coque T, Werner G, Sundsfjord A . Mobile genetic elements and their contribution to the emergence of antimicrobial resistant Enterococcus faecalis and Enterococcus faecium. Clin Microbiol Infect. 2010; 16(6):541-54. DOI: 10.1111/j.1469-0691.2010.03226.x. View

16.

Carlander D, Larsson A . Avian antibodies can eliminate interference due to complement activation in ELISA. Ups J Med Sci. 2002; 106(3):189-95. DOI: 10.3109/2000-1967-145. View

17.

Merrill K, Hanson S, Sumner S, Vento T, Veillette J, Webb B . Antimicrobial stewardship: Staff nurse knowledge and attitudes. Am J Infect Control. 2019; 47(10):1219-1224. DOI: 10.1016/j.ajic.2019.03.022. View

18.

Bachtiar E, Afdhal A, Meidyawati R, Soejoedono R, Poerwaningsih E . Effect of topical anti-Streptococcus mutans IgY gel on quantity of S. mutans on rats' tooth surface. Acta Microbiol Immunol Hung. 2016; 63(2):159-69. DOI: 10.1556/030.63.2016.2.2. View

19.

Nilsson E, Kollberg H, Johannesson M, Wejaker P, Carlander D, Larsson A . More than 10 years' continuous oral treatment with specific immunoglobulin Y for the prevention of Pseudomonas aeruginosa infections: a case report. J Med Food. 2007; 10(2):375-8. DOI: 10.1089/jmf.2006.214. View

20.

Wallach M, Webby R, Islam F, Walkden-Brown S, Emmoth E, Feinstein R . Cross-protection of chicken immunoglobulin Y antibodies against H5N1 and H1N1 viruses passively administered in mice. Clin Vaccine Immunol. 2011; 18(7):1083-90. PMC: 3147324. DOI: 10.1128/CVI.05075-11. View