John C Atherton
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Explore the profile of John C Atherton including associated specialties, affiliations and a list of published articles.
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Articles
57
Citations
2575
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Recent Articles
1.
Kaneko K, Zaitoun A, Letley D, Rhead J, Torres J, Spendlove I, et al.
J Pathol
. 2022 Jul;
258(2):199-209.
PMID: 35851954
High-level expression of decay-accelerating factor, CD55, has previously been found in human gastric cancer (GC) and intestinal metaplasia (IM) tissues. Therapeutic effects of CD55 inhibition in cancer have been reported....
2.
Robinson K, Atherton J
Annu Rev Pathol
. 2020 Nov;
16:123-144.
PMID: 33197219
is the leading cause of peptic ulcer disease. The infection has been implicated in more than 75% of duodenal ulcer cases and 17% of gastric ulcer cases. has been classified...
3.
White J, Sami S, Reddiar D, Mannath J, Ortiz-Fernandez-Sordo J, Beg S, et al.
Scand J Gastroenterol
. 2019 Jan;
53(12):1611-1618.
PMID: 30600732
Background: Patient outcomes in gastric adenocarcinoma are poor due to late diagnosis. Detecting and treating at the premalignant stage has the potential to improve this. Helicobacter pylori is also a...
4.
A GWAS on Helicobacter pylori strains points to genetic variants associated with gastric cancer risk
Berthenet E, Yahara K, Thorell K, Pascoe B, Meric G, Mikhail J, et al.
BMC Biol
. 2018 Aug;
16(1):84.
PMID: 30071832
Background: Helicobacter pylori are stomach-dwelling bacteria that are present in about 50% of the global population. Infection is asymptomatic in most cases, but it has been associated with gastritis, gastric...
5.
Sinnett C, Letley D, Narayanan G, Patel S, Hussein N, Zaitoun A, et al.
J Clin Pathol
. 2016 May;
69(11):968-973.
PMID: 27189958
Aims: Helicobacter pylori infection is the major cause of peptic ulceration and gastric cancer, and an important virulence determinant is its vacuolating cytotoxin vacA. Previously, we have described allelic variation...
6.
Hussain K, Letley D, Greenaway A, Kenefeck R, Winter J, Tomlinson W, et al.
Front Immunol
. 2016 Mar;
7:71.
PMID: 27014260
Helicobacter pylori infections are usually established in early childhood and continuously stimulate immunity, including T-helper 1 (Th1), Th17, and regulatory T-cell (Treg) responses, throughout life. Although known to be the...
7.
Onion D, Argent R, Reece-Smith A, Craze M, Pineda R, Clarke P, et al.
Mol Cancer Ther
. 2016 Feb;
15(4):753-63.
PMID: 26873730
There is a growing recognition that current preclinical models do not reflect the tumor microenvironment in cellular, biological, and biophysical content and this may have a profound effect on drug...
8.
Ferreira R, Machado J, Letley D, Atherton J, Pardo M, Gonzalez C, et al.
J Clin Microbiol
. 2016 Jan;
54(2):507.
PMID: 26822771
No abstract available.
9.
Amilon K, Letley D, Winter J, Robinson K, Atherton J
Mol Microbiol
. 2015 Aug;
98(5):831-46.
PMID: 26259667
The vacuolating cytotoxin, VacA, is an important virulence factor secreted by the gastric pathogen Helicobacter pylori. Certain vacA genotypes are strongly associated with disease risk, but the association is not...
10.