» Articles » PMID: 14707090

The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-induced T Cell Polarization

Overview
Journal J Immunol
Date 2004 Jan 7
PMID 14707090
Citations 141
Authors
Affiliations
Soon will be listed here.
Abstract

Dendritic cells (DC) are instrumental in orchestrating an appropriately polarized Th cell response to pathogens. DC exhibit considerable phenotypic and functional plasticity, influenced by lineage, Ag engagement, and the environment in which they develop and mature. In this study, we identify the human cationic peptide LL-37, found in abundance at sites of inflammation, as a potent modifier of DC differentiation, bridging innate and adaptive immune responses. LL-37-derived DC displayed significantly up-regulated endocytic capacity, modified phagocytic receptor expression and function, up-regulated costimulatory molecule expression, enhanced secretion of Th-1 inducing cytokines, and promoted Th1 responses in vitro. LL-37 may be an attractive therapeutic candidate for manipulating T cell polarization by DC.

Citing Articles

Metformin-mediated intestinal AMPK activation ameliorates PCOS through gut microbiota modulation and metabolic pathways.

Xu Y, Ning L, Si Y, Li X, Wang R, Ren Q Front Endocrinol (Lausanne). 2025; 16:1526109.

PMID: 40041289 PMC: 11876036. DOI: 10.3389/fendo.2025.1526109.


Cathelicidins: Opportunities and Challenges in Skin Therapeutics and Clinical Translation.

Dzurova L, Holaskova E, Pospisilova H, Schneider Rauber G, Frebortova J Antibiotics (Basel). 2025; 14(1).

PMID: 39858288 PMC: 11762488. DOI: 10.3390/antibiotics14010001.


Immune Responses Elicited by Outer Membrane Vesicles of Gram-Negative Bacteria: Important Players in Vaccine Development.

Velimirov B, Velimirov B Life (Basel). 2025; 14(12.

PMID: 39768292 PMC: 11678573. DOI: 10.3390/life14121584.


Immunomodulatory peptides: new therapeutic horizons for emerging and re-emerging infectious diseases.

Chatterjee D, Sivashanmugam K Front Microbiol. 2025; 15:1505571.

PMID: 39760081 PMC: 11695410. DOI: 10.3389/fmicb.2024.1505571.


Antiparasitic Evaluation of Aquiluscidin, a Cathelicidin Obtained from , and the Vcn-23 Derivative Peptide against , and .

Hernandez-Arvizu E, Asada M, Kawazu S, Vega C, Rodriguez-Torres A, Morales-Garcia R Pathogens. 2024; 13(6).

PMID: 38921794 PMC: 11206629. DOI: 10.3390/pathogens13060496.