Airway Microbiome-immune Crosstalk in Chronic Obstructive Pulmonary Disease

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2023 Feb 6

PMID 36741369

Authors

Alex Kayongo

Nicole M Robertson

Trishul Siddharthan

Moses Levi Ntayi

Josephine Caren Ndawula

Obondo J Sande

Bernard S Bagaya

Bruce Kirenga

Harriet Mayanja-Kizza

Moses L Joloba

Sofia K Forslund

Affiliations

Soon will be listed here.

Abstract

Chronic Obstructive Pulmonary Disease (COPD) has significantly contributed to global mortality, with three million deaths reported annually. This impact is expected to increase over the next 40 years, with approximately 5 million people predicted to succumb to COPD-related deaths annually. Immune mechanisms driving disease progression have not been fully elucidated. Airway microbiota have been implicated. However, it is still unclear how changes in the airway microbiome drive persistent immune activation and consequent lung damage. Mechanisms mediating microbiome-immune crosstalk in the airways remain unclear. In this review, we examine how dysbiosis mediates airway inflammation in COPD. We give a detailed account of how airway commensal bacteria interact with the mucosal innate and adaptive immune system to regulate immune responses in healthy or diseased airways. Immune-phenotyping airway microbiota could advance COPD immunotherapeutics and identify key open questions that future research must address to further such translation.

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