Synthesis and Pharmacological Evaluation of Prenylated and Benzylated Pterocarpans Against Snake Venom

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2003 Dec 31

PMID 14698175

Citations 6

Authors

Alcides J M da Silva

Antonio L Coelho

Alessandro B C Simas

Raphael A M Moraes

Diogo A Pinheiro

Fabricio F A Fernandes

Emerson Z Arruda

Paulo R R Costa

Paulo A Melo

Affiliations

Soon will be listed here.

Abstract

Edunol (3), a pterocarpan isolated from Harpalyce brasiliana, a plant used in the northeast of Brazil against snakebites, was obtained by synthesis and showed antimyotoxic, antiproteolytic and PLA2 inhibitor properties. These proprieties could be improved through the synthesis of a bioisoster (5), where the prenyl group was replaced by the benzyl group.

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