Human Hematopoietic Stem Cell Adherence to Cytokines and Matrix Molecules

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1992 Jul 1

PMID 1378855

Citations 13

Authors

M W Long

R Briddell

A W Walter

E Bruno

R Hoffman

Affiliations

Soon will be listed here.

Abstract

The hematopoietic microenvironment is a complex structure in which stem cells, progenitor cells, stromal cells, growth factors, and extracellular matrix (ECM) molecules each interact to direct the coordinate regulation of blood cell development. While much is known concerning the individual components of this microenvironment, little is understood of the interactions among these various components or, in particular, the nature of those interactions responsible for the regional localization of specific developmental signals. We hypothesized that cytokines act together with ECM molecules to anchor stem cells within the microenvironment, thus modulating their function. In order to analyze matrix-cytokine-stem cell interactions, we developed an ECM model system in which purified stem cell populations and plastic-immobilized individual proteins are used to assess the role of various matrix molecules and/or cytokines in human hematopoietic cell development. Analysis of these interactions revealed that a single ECM protein, thrombospondin, in conjunction with a single cytokine (e.g., c-kit ligand), constitutes a developmental signal that synergistically modulates hematopoietic stem cell function.

Citing Articles

The extracellular matrix of hematopoietic stem cell niches.

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New Insights Into the Differentiation of Megakaryocytes From Hematopoietic Progenitors.

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Divergent modulation of normal and neoplastic stem cells by thrombospondin-1 and CD47 signaling.

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Covalent immobilization of stem cell factor and stromal derived factor 1α for in vitro culture of hematopoietic progenitor cells.

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Effect of bone marrow-derived extracellular matrix on cardiac function after ischemic injury.

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