Synthesis Characterization and Anticancer Activity Studies on Some Mannich Bases Derived from 1,2,4-triazoles

Overview

Journal Eur J Med Chem

Specialty Chemistry

Date 2003 Aug 23

PMID 12932907

Citations 48

Authors

B Shivarama Holla

B Veerendra

M K Shivananda

Boja Poojary

Affiliations

Soon will be listed here.

Abstract

A series of 3-substituted 4-[5-(4-methoxy-2-nitrophenyl)-2-furfurylidene] amino-5-mercapto-1,2,4-triazoles (3) were synthesized. Aminomethylation of compounds 3 with formaldehyde and various secondary amines furnished Mannich bases 4 and 5. These compounds were characterized on the basis of IR, 1H-NMR, mass spectral data and elemental analysis. The newly synthesized compounds were screened for their anticancer activity against a panel of 60 cell lines derived from seven cancer types namely, lung, colon, melanoma, renal, ovarian, CNS and leukemia. Some of the compounds were slightly more potent.

Citing Articles

Synthesis, crystal structure, Hirshfeld surface analysis, and DFT calculation of 4-(5-(((1-(3,4,5-trimethoxyphenyl)-1-1,2,3-triazol-4-yl)methyl)thio)-4-phenyl-4-1,2,4-triazol-3-yl)pyridine.

El-Naggar M, Hasan K, Khanfar M, Delmani F, Shehadi I, Al-Qawasmeh R Heliyon. 2024; 10(22):e40318.

PMID: 39605836 PMC: 11600039. DOI: 10.1016/j.heliyon.2024.e40318.

Synthesis, crystal structure and Hirshfeld surface analysis of 1-[(1-octyl-1-1,2,3-triazol-4-yl)methyl]-3-phenyl-1,2-di-hydro-quinoxalin-2(1)-one.

Abad N, Mague J, Kalonji Mubengayi C, Alsubari A, Essassi E, Ramli Y Acta Crystallogr E Crystallogr Commun. 2024; 80(Pt 9):936-941.

PMID: 39267873 PMC: 11389679. DOI: 10.1107/S2056989024007746.

Application of the Mannich reaction in the structural modification of natural products.

Pu M, Guo H, Quan Z, Li X, Shen Q J Enzyme Inhib Med Chem. 2023; 38(1):2235095.

PMID: 37449337 PMC: 10351470. DOI: 10.1080/14756366.2023.2235095.

Design, Synthesis and Biological Activities of (Thio)Urea Benzothiazole Derivatives.

Mendieta-Wejebe J, Rosales-Hernandez M, Padilla-Martinez I, Garcia-Baez E, Cruz A Int J Mol Sci. 2023; 24(11).

PMID: 37298442 PMC: 10253887. DOI: 10.3390/ijms24119488.

Zn Complex on Tryptophan-Functionalized MCM-41 as an Efficient and Promising Reusable Nanocatalyst in One-Pot Three-Component Synthesis of Amino Benzyl Quinolinols and Naphthols via a Betti Reaction.

Hamedimehr S, Ojaghi Aghbash K, Noroozi Pesyan N ACS Omega. 2023; 8(9):8227-8236.

PMID: 36910969 PMC: 9996610. DOI: 10.1021/acsomega.2c05723.