Antimicrobial Metal-based Thiophene Derived Compounds

Overview

Journal J Enzyme Inhib Med Chem

Specialty Biochemistry

Date 2016 Oct 22

PMID 27766891

Citations 6

Authors

Shakeela Yasmeen

Sajjad Hussain Sumrra

Muhammad Safwan Akram

Zahid H Chohan

Affiliations

Soon will be listed here.

Abstract

A novel series of thiophene derived Schiff bases and their transition metal- [Co(II), Cu(II), Zn(II), Ni(II)] based compounds are reported. The Schiff bases act as tridentate ligands toward metal ions via azomethine-N, deprotonated-N of ammine substituents and S-atom of thienyl moiety. The synthesized ligands along with their metal complexes were screened for their in vitro antibacterial activity against six bacterial pathogens (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and for antifungal activity against six fungal pathogens (Trichophytonlongifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata). The results of antimicrobial studies revealed the free ligands to possess potential activity which significantly increased upon chelation.

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