Synthesis and Antimicrobial Activity of 4-Substituted 1,2,3-Triazole-Coumarin Derivatives

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2018 Jan 19

PMID 29346325

Citations 18

Authors

Priscila Lopez-Rojas

Monika Janeczko

Konrad Kubinski

Angel Amesty

Maciej Maslyk

Ana Estevez-Braun

Affiliations

Soon will be listed here.

Abstract

A new series of coumarin-1,2,3-triazole conjugates with varied alkyl, phenyl and heterocycle moieties at C-4 of the triazole nucleus were synthesized using a copper(I)-catalysed Huisgen 1,3-dipolar cycloaddition reaction of corresponding -propargylated coumarin () or -propargylated coumarin () with alkyl or aryl azides. Based on their minimal inhibitory concentrations (MICs) against selected microorganisms, six out of twenty-six compounds showed significant antibacterial activity towards (MIC = 12.5-50 µg/mL). Moreover, the synthesized triazoles show relatively low toxicity against human erythrocytes.

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