An Angiogenic Role for the Human Peptide Antibiotic LL-37/hCAP-18

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2003 Jun 5

PMID 12782669

Citations 283

Authors

Rembert Koczulla

Georges von Degenfeld

Christian Kupatt

Florian Krotz

Stefan Zahler

Torsten Gloe

Katja Issbrucker

Pia Unterberger

Mohamed Zaiou

Corinna Lebherz

Alexander Karl

Philip Raake

Achim Pfosser

Peter Boekstegers

Ulrich Welsch

Pieter S Hiemstra

Claus Vogelmeier

Richard L Gallo

Matthias Clauss

Robert Bals

Affiliations

Soon will be listed here.

Abstract

Antimicrobial peptides are effector molecules of the innate immune system and contribute to host defense and regulation of inflammation. The human cathelicidin antimicrobial peptide LL-37/hCAP-18 is expressed in leukocytes and epithelial cells and secreted into wound and airway surface fluid. Here we show that LL-37 induces angiogenesis mediated by formyl peptide receptor-like 1 expressed on endothelial cells. Application of LL-37 resulted in neovascularization in the chorioallantoic membrane assay and in a rabbit model of hind-limb ischemia. The peptide directly activates endothelial cells, resulting in increased proliferation and formation of vessel-like structures in cultivated endothelial cells. Decreased vascularization during wound repair in mice deficient for CRAMP, the murine homologue of LL-37/hCAP-18, shows that cathelicidin-mediated angiogenesis is important for cutaneous wound neovascularization in vivo. Taken together, these findings demonstrate that LL-37/hCAP-18 is a multifunctional antimicrobial peptide with a central role in innate immunity by linking host defense and inflammation with angiogenesis and arteriogenesis.

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