Bioinformatic Analysis and Experimental Validation Implicate STAT2-mediated Angiogenic Responses in Rosacea Pathogenesis

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 2025 Feb 13

PMID 39945902

Authors

Bancheng Chen

Chenchen Wu

Yan Liao

Hao Hu

Xiaojuan Liu

Chao Chen

Xiaoming Liu

Lin Wu

Xiaofan Chen

Bo Yu

Affiliations

Soon will be listed here.

Abstract

Rosacea is a chronic skin condition characterized by facial erythema, flushing, and telangiectasia. Abnormalities in the vascular responses are associated with the development of rosacea. Our analysis of the GSE65914 dataset revealed differential expression of angiogenesis-related genes in rosacea lesions classified rosacea samples with distinct angiogenic molecular patterns. Further investigation of immune infiltration characteristics across angiogenic patterns identified unique immune signatures associated with VEGFA MMP9 and VEGFA MMP9 subtypes. Moreover, STAT2 proteins were higher in the VEGFA MMP9 pattern group. Increased expression of STAT2 was confirmed in rosacea patients and in the mice model of rosacea induced by LL37. Knockdown of STAT2 suppressed the tube formation ability of human umbilical vein endothelial cells, which implicated STAT2 participated in regulating angiogenic responses. In conclusion, our study characterized rosacea subtypes by distinct angiogenic molecular patterns and found that STAT2 may play a critical role in the regulation of angiogenic responses in rosacea. These insights may provide a promising target of rosacea therapies.

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