Translational Control in the Endoplasmic Reticulum Stress Response

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2002 Nov 20

PMID 12438433

Citations 356

Authors

David Ron

Affiliations

Soon will be listed here.

Citing Articles

Biogenesis of stress granules and their role in the regulation of stress-induced male reproduction disorders.

Li J, Shen L, Wang K, Wu S, Wang Y, Pan Y Cell Commun Signal. 2025; 23(1):84.

PMID: 39948590 PMC: 11827146. DOI: 10.1186/s12964-025-02054-w.

Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in mice.

Deng Y, Yang X, Ye X, Yuan Y, Zhang Y, Teng F Life Metab. 2025; 3(3):loae009.

PMID: 39872376 PMC: 11749235. DOI: 10.1093/lifemeta/loae009.

Production of Amyloid-β in the Aβ-Protein-Precursor Proteolytic Pathway Is Discontinued or Severely Suppressed in Alzheimer's Disease-Affected Neurons: Contesting the 'Obvious'.

Volloch V, Rits-Volloch S Genes (Basel). 2025; 16(1.

PMID: 39858593 PMC: 11764795. DOI: 10.3390/genes16010046.

Reducing Cofilin dosage makes embryos resilient to heat stress.

Biel N, Rashid F, Natua S, Wang T, Chou T, Nguyen T bioRxiv. 2025; .

PMID: 39803506 PMC: 11722379. DOI: 10.1101/2025.01.02.631102.

Exploring the dual role of endoplasmic reticulum stress in urological cancers: Implications for tumor progression and cell death interactions.

Farahani N, Alimohammadi M, Raei M, Nabavi N, Aref A, Hushmandi K J Cell Commun Signal. 2024; 18(4):e12054.

PMID: 39691874 PMC: 11647052. DOI: 10.1002/ccs3.12054.

References

Novoa I, Zeng H, Harding H, Ron D . Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J Cell Biol. 2001; 153(5):1011-22. PMC: 2174339. DOI: 10.1083/jcb.153.5.1011. View

Tan S, Somia N, Maher P, Schubert D . Regulation of antioxidant metabolism by translation initiation factor 2alpha. J Cell Biol. 2001; 152(5):997-1006. PMC: 2198799. DOI: 10.1083/jcb.152.5.997. View

Harding H, Zeng H, Zhang Y, Jungries R, Chung P, Plesken H . Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol Cell. 2001; 7(6):1153-63. DOI: 10.1016/s1097-2765(01)00264-7. View

Scheuner D, Song B, McEwen E, Liu C, Laybutt R, Gillespie P . Translational control is required for the unfolded protein response and in vivo glucose homeostasis. Mol Cell. 2001; 7(6):1165-76. DOI: 10.1016/s1097-2765(01)00265-9. View

Sonenberg N, Newgard C . Protein synthesis. The perks of balancing glucose. Science. 2001; 293(5531):818-9. DOI: 10.1126/science.1062937. View

Han A, Yu C, Lu L, Fujiwara Y, Browne C, Chin G . Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J. 2001; 20(23):6909-18. PMC: 125753. DOI: 10.1093/emboj/20.23.6909. View

Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K . XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 2002; 107(7):881-91. DOI: 10.1016/s0092-8674(01)00611-0. View

Harding H, Novoa I, Zhang Y, Zeng H, Wek R, Schapira M . Regulated translation initiation controls stress-induced gene expression in mammalian cells. Mol Cell. 2000; 6(5):1099-108. DOI: 10.1016/s1097-2765(00)00108-8. View

Calfon M, Zeng H, Urano F, Till J, Hubbard S, Harding H . IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 2002; 415(6867):92-6. DOI: 10.1038/415092a. View

10.

Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E . Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. J Clin Invest. 2002; 109(4):525-32. PMC: 150879. DOI: 10.1172/JCI14550. View

11.

Dever T . Gene-specific regulation by general translation factors. Cell. 2002; 108(4):545-56. DOI: 10.1016/s0092-8674(02)00642-6. View

12.

Bucciantini M, Giannoni E, Chiti F, Baroni F, Formigli L, Zurdo J . Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases. Nature. 2002; 416(6880):507-11. DOI: 10.1038/416507a. View

13.

Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J . The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol. 2002; 22(11):3864-74. PMC: 133833. DOI: 10.1128/MCB.22.11.3864-3874.2002. View

14.

Kaufman R, Scheuner D, Schroder M, Shen X, Lee K, Liu C . The unfolded protein response in nutrient sensing and differentiation. Nat Rev Mol Cell Biol. 2002; 3(6):411-21. DOI: 10.1038/nrm829. View

15.

Kaufman R . Orchestrating the unfolded protein response in health and disease. J Clin Invest. 2002; 110(10):1389-98. PMC: 151822. DOI: 10.1172/JCI16886. View

16.

Harding H, Novoa I, Bertolotti A, Zeng H, Zhang Y, Urano F . Translational regulation in the cellular response to biosynthetic load on the endoplasmic reticulum. Cold Spring Harb Symp Quant Biol. 2003; 66:499-508. DOI: 10.1101/sqb.2001.66.499. View

17.

Wolcott C, Rallison M . Infancy-onset diabetes mellitus and multiple epiphyseal dysplasia. J Pediatr. 1972; 80(2):292-7. DOI: 10.1016/s0022-3476(72)80596-1. View

18.

Hightower L . Heat shock, stress proteins, chaperones, and proteotoxicity. Cell. 1991; 66(2):191-7. DOI: 10.1016/0092-8674(91)90611-2. View

19.

Gething M, Sambrook J . Protein folding in the cell. Nature. 1992; 355(6355):33-45. DOI: 10.1038/355033a0. View

20.

Macejak D, Sarnow P . Translational regulation of the immunoglobulin heavy-chain binding protein mRNA. Enzyme. 1990; 44(1-4):310-9. DOI: 10.1159/000468767. View