Quintessential Synergy: Concurrent Transient Administration of Integrated Stress Response Inhibitors and BACE1 And/or BACE2 Activators As the Optimal Therapeutic Strategy for Alzheimer's Disease

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Sep 28

PMID 39337400

Authors

Vladimir Volloch

Sophia Rits-Volloch

Affiliations

Soon will be listed here.

Abstract

The present study analyzes two potential therapeutic approaches for Alzheimer's disease (AD). One is the suppression of the neuronal integrated stress response (ISR). Another is the targeted degradation of intraneuronal amyloid-beta (Aβ) via the activation of BACE1 (Beta-site Aβ-protein-precursor Cleaving Enzyme) and/or BACE2. Both approaches are rational. Both are promising. Both have substantial intrinsic limitations. However, when combined in a carefully orchestrated manner into a composite therapy they display a prototypical synergy and constitute the apparently optimal, potentially most effective therapeutic strategy for AD.

Citing Articles

Production of Amyloid-β in the Aβ-Protein-Precursor Proteolytic Pathway Is Discontinued or Severely Suppressed in Alzheimer's Disease-Affected Neurons: Contesting the 'Obvious'.

Volloch V, Rits-Volloch S Genes (Basel). 2025; 16(1.

PMID: 39858593 PMC: 11764795. DOI: 10.3390/genes16010046.

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