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Comparison of a Radioimmunoassay with an Enzymatic Assay for Gentamicin

Overview
Journal Antimicrob Agents Chemother
Publisher American Society for Microbiology
Specialty Pharmacology
Date 1975 Jan 1
PMID 1137354
Citations 7
Authors
B H Minshew
R K Holmes
C R BAXTER
Affiliations
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Abstract

A radioimmunoassay and an enzymatic assay for gentamicin have been compared. The correlation coefficient for results of gentamicin assays performed by the two methods with 45 serum specimens was 0.90. A similar standard curve for the radioimmunoassay was obtained with gentamicin complex, with gentamicin Cl, Cla, or C2, or with sisomicin as ligand, but tobramycin did not compete with [(3)H]gentamicin for binding to the antiserum.

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Therapeutic drug monitoring of aminoglycoside antibiotics.

Reeves D Infection. 1980; 8 Suppl 3:S 313-20.

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References
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