Enzymatic Acetylation As a Means of Determining Serum Aminoglycoside Concentrations

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1973 Oct 1

PMID 4791309

Citations 22

Authors

M J Haas

J Davies

Affiliations

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Abstract

A rapid and accurate enzymatic assay has been developed for the determination of blood serum levels of BB-K8 and other suitable aminoglycoside antibiotics.

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References

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Umezawa H, Okanishi M, UTAHARA R, Maeda K, Kondo S . Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli. J Antibiot (Tokyo). 1967; 20(3):136-41. View

Benveniste R, Davies J . Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor. Biochemistry. 1971; 10(10):1787-96. DOI: 10.1021/bi00786a009. View

Smith D, Van Otto B, Smith A . A rapid chemical assay for gentamicin. N Engl J Med. 1972; 286(11):583-6. DOI: 10.1056/NEJM197203162861106. View

Brzezinska M, Benveniste R, Davies J, Daniels P, Weinstein J . Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymatic N-acetylation of the deoxystreptamine moiety. Biochemistry. 1972; 11(5):761-5. DOI: 10.1021/bi00755a013. View