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Macrophage Plasminogen Activator: Induction by Asbestos is Blocked by Anti-inflammatory Steroids

Overview
Journal J Exp Med
Specialties Allergy & Immunology
General Medicine
Date 1976 Dec 1
PMID 1003109
Citations 24
Authors
J Hamilton
J D Vassalli
E Reich
Affiliations
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Abstract

Intraperitoneal injection of asbestos fibres into mice induces the formation of exudates containing macrophages that produce plasminogen activator. Like-wise, in vitro addition of asbestos to macrophage cultures stimulates plasminogen activator secretion; the synthesis and secretion of lysozyme and lysosomal enzymes are not changed under these conditions. The enhanced secretion of plasminogen activator by macrophages exposed to asbestos is suppressed by low concentrations of anti-inflammatory steroids.

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Uptake of aggregated immunoglobulin by the mouse kidney. II. Effect of hydrocortisone.

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References
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