Interactions of Asbestos-activated Macrophages with an Experimental Fibrosarcoma

Overview

Journal Environ Health Perspect

Date 1983 Sep 1

PMID 6315388

Authors

K Donaldson

J M Davis

A Ewing

K JAMES

Affiliations

Soon will be listed here.

Abstract

Supernatants from in vivo asbestos-activated macrophages failed to show any cytostatic activity against a syngeneic fibrosarcoma cell line in vitro. UICC chrysotile-induced peritoneal exudate cells also failed to demonstrate any growth inhibitory effect on the same cells in Winn assays of tumor growth. Mixing UICC crocidolite with inoculated tumor cells resulted in a dose-dependent inhibition of tumor growth; this could, however, be explained by a direct cytostatic effect on the tumor cells of high doses of crocidolite, which was observed in vitro.

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