Disease Models & Mechanisms
Overview
Disease Models & Mechanisms is a peer-reviewed scientific journal that focuses on the use of animal models to study human diseases. It covers a wide range of topics, including genetics, cell biology, and physiology, providing valuable insights into disease mechanisms and potential therapeutic approaches. The journal aims to bridge the gap between basic research and clinical applications, making it an essential resource for researchers and clinicians in the field of disease modeling.
Details
Details
Abbr.
Dis Model Mech
Start
2008
End
Continuing
Frequency
Six no. a year, 2011-
p-ISSN
1754-8403
e-ISSN
1754-8411
Country
United Kingdom
Language
English
Specialty
General Medicine
Metrics
Metrics
h-index / Ranks: 2769
107
SJR / Ranks: 2287
1361
CiteScore / Ranks: 2534
7.50
JIF / Ranks: 2027
4.3
Recent Articles
11.
12.
Ng W, Wang L
Dis Model Mech
. 2025 Feb;
18(9).
PMID: 39968756
Bats are a natural reservoir for a wide variety of notorious viruses that are deadly to humans and other mammals but cause no or minimal clinical damage in bats. The...
13.
Badger S, Coldicott I, Kyrgiou-Balli E, Higginbottom A, Moutin C, Mohd Imran K, et al.
Dis Model Mech
. 2025 Feb;
18(2).
PMID: 39945358
C9orf72-related amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) has proven difficult to model in mice. Liu et al. (2016) reported a bacterial artificial chromosome (BAC) transgenic mouse displaying behavioural, motor and...
14.
Simon A, Djeddi S, Bournon P, Reiss D, Thompson J, Laporte J
Dis Model Mech
. 2025 Feb;
18(2).
PMID: 39945189
Gene differential expression and alternative splicing are mechanisms that give rise to a plethora of tissue-specific transcripts. Although these mechanisms have been studied in various tissues, their role during muscle...
15.
Gopal Krishnan P, Lee W, Goh K, Choy S, Turqueza L, Lim Z, et al.
Dis Model Mech
. 2025 Feb;
18(2).
PMID: 39925192
Muscle stem cells (MuSCs) are essential for the regenerative capabilities of skeletal muscles. MuSCs are maintained in a quiescent state, but, when activated, can undergo proliferation and differentiation into myocytes,...
16.
Uusi-Makela M, Harjula S, Junno M, Sillanpaa A, Natkin R, Niskanen M, et al.
Dis Model Mech
. 2025 Feb;
PMID: 39916610
Inflammasome regulates the host response to intracellular pathogens including mycobacteria. We have previously shown that the course of Mycobacterium marinum infection in adult zebrafish (Danio rerio) mimics the course of...
17.
Thornton M, Sommer N, McGonigle M, Kumar Ram A, Yerrathota S, Ehirim H, et al.
Dis Model Mech
. 2025 Feb;
18(2).
PMID: 39910908
Anti-retroviral therapy (ART) has decreased human immunodeficiency virus (HIV)-1-associated morbidity. However, despite ART, immune cells remain latently infected, leading to chronic inflammation and HIV-1-associated comorbidities. New strategies are needed to...
18.
Verhaeg M, Verhaeg M, van der Pijl E, van der Pijl E, van de Vijver D, van de Vijver D, et al.
Dis Model Mech
. 2025 Jan;
18(2).
PMID: 39885828
Duchenne muscular dystrophy is a severe neuromuscular disorder, caused by mutations in the DMD gene. Normally, the DMD gene gives rise to many dystrophin isoforms, of which multiple are expressed...
19.
Tweedie L, Tweedie L, Riccetti M, Riccetti M, Cain B, Cain B, et al.
Dis Model Mech
. 2025 Jan;
18(2).
PMID: 39882631
Gsx2 is a homeodomain transcription factor critical for development of the ventral telencephalon and hindbrain in mouse. Loss of Gsx2 function results in severe basal ganglia dysgenesis and defects in...
20.
Srnic N, Westcott F, Caney E, Hodson L
Dis Model Mech
. 2025 Jan;
18(1).
PMID: 39878508
The excessive accumulation of intrahepatic triglyceride (IHTG) in the liver is a risk factor for metabolic diseases, including type 2 diabetes and cardiovascular disease. IHTG can excessively accumulate owing to...