Zurab Siprashvili
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Explore the profile of Zurab Siprashvili including associated specialties, affiliations and a list of published articles.
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35
Citations
2143
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Recent Articles
1.
Yang X, He F, Porter D, Garbett K, Meyers R, Reynolds D, et al.
bioRxiv
. 2025 Mar;
PMID: 40060693
Homeostasis relies on signaling networks controlled by cell membrane receptors. Although G-protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors, their specific roles in the epidermis are not fully...
2.
Kellman L, Neela P, Srinivasan S, Siprashvili Z, Shanderson R, Hong A, et al.
Nat Genet
. 2025 Feb;
57(3):718-728.
PMID: 39962238
Single-nucleotide variants (SNVs) in regulatory DNA are linked to inherited cancer risk. Massively parallel reporter assays of 4,041 SNVs linked to 13 neoplasms comprising >90% of human malignancies were performed...
3.
Miao W, Porter D, Siprashvili Z, Ferguson I, Ducoli L, Nguyen D, et al.
Cell Rep
. 2025 Jan;
44(1):115174.
PMID: 39764852
Glucose binding can alter protein oligomerization to enable differentiation. Here, we demonstrate that glucose binding is a general capacity of DExD/H-box RNA helicases, including DDX50, which was found to be...
4.
Winge M, Nasrallah M, Jackrazi L, Guo K, Fuhriman J, Szafran R, et al.
Sci Transl Med
. 2024 Dec;
16(777):eade5915.
PMID: 39661704
Inflammatory skin disease is characterized by a pathologic interplay between skin cells and immunocytes and can result in disfiguring cutaneous lesions and systemic inflammation. Immunosuppression is commonly used to target...
5.
Porter D, Meyers R, Miao W, Reynolds D, Hong A, Yang X, et al.
bioRxiv
. 2024 Nov;
PMID: 39605549
Identifying noncoding single nucleotide variants ( SNVs ) in regulatory DNA linked to polygenic disease risk, the transcription factors ( TFs ) they bind, and the target genes they dysregulate...
6.
Kim G, Siprashvili Z, Yang X, Meyers J, Ji A, Khavari P, et al.
bioRxiv
. 2024 Oct;
PMID: 39464078
Cutaneous squamous cell carcinoma (cSCC) accounts for 20% of all skin cancer deaths globally, making it the second-highest subtype of skin cancer. The prevalence of cSCC in humans, as well...
7.
Shanderson R, Ferguson I, Siprashvili Z, Ducoli L, Li A, Miao W, et al.
bioRxiv
. 2024 Mar;
PMID: 38496616
Raf kinases play vital roles in normal mitogenic signaling and cancer, however, the identities of functionally important Raf-proximal proteins throughout the cell are not fully known. Raf1 proximity proteomics/BioID in...
8.
Guo M, Reynolds D, Ang C, Liu Y, Zhao Y, Donohue L, et al.
Nat Genet
. 2023 Oct;
55(11):1876-1891.
PMID: 37857935
Noncoding variants of presumed regulatory function contribute to the heritability of neuropsychiatric disease. A total of 2,221 noncoding variants connected to risk for ten neuropsychiatric disorders, including autism spectrum disorder,...
9.
Miao W, Porter D, Lopez-Pajares V, Siprashvili Z, Meyers R, Bai Y, et al.
Cell
. 2023 Jan;
186(1):80-97.e26.
PMID: 36608661
Glucose is a universal bioenergy source; however, its role in controlling protein interactions is unappreciated, as are its actions during differentiation-associated intracellular glucose elevation. Azido-glucose click chemistry identified glucose binding...
10.
So J, Nazaroff J, Iwummadu C, Harris N, Gorell E, Fulchand S, et al.
Orphanet J Rare Dis
. 2022 Oct;
17(1):377.
PMID: 36253825
Background: Recessive dystrophic epidermolysis bullosa (RDEB) is a rare, devastating blistering genodermatosis caused by mutations in the COL7A1 gene, which encodes for type VII collagen and is necessary for dermal-epidermal...