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» Authors » Zsolt Nemethy

Zsolt Nemethy

Explore the profile of Zsolt Nemethy including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 16
Citations 206
Followers 0
Related Specialties
Chemistry
Biochemistry
Pharmacology
Top 10 Co-Authors
Balazs Lendvai
Ottilia Balazs
Istvan Ledneczki
Bela Kiss
Istvan Greiner
Gyorgy Levay
Sandor Maho
Pal Tapolcsanyi
Janos Eles
Monika Vastag
Published In
Bioorg Med Chem Lett
Eur J Med Chem
J Med Chem
J Biomol Screen
Brain Res Bull
Affiliations
Soon will be listed here.
Recent Articles
11.
Charting the chemical space around the (iso)indoline scaffold, a comprehensive approach towards multitarget directed ligands
Elias O, Kovacs Z, Wagner G, Nemethy Z, Tarcsay A, Greiner I
Bioorg Med Chem Lett . 2016 Aug; 26(17):4211-5. PMID: 27496213
Within the framework of orthosteric G protein coupled receptor (GPCR) polypharmacology herein we report the systematic elaboration and thorough evaluation of a data matrix generated by sampling the chemical space...
12.
The influence of 5-HT(2A) activity on a 5-HT(2C) specific in vivo assay used for early identification of multiple acting SERT and 5-HT(2C) receptor ligands
Elias O, Nogradi K, Domany G, Szakacs Z, Koti J, Szantay Jr C, et al.
Bioorg Med Chem Lett . 2016 Jan; 26(3):914-920. PMID: 26748694
As a result of our exploratory programme aimed at elaborating dually acting compounds towards the serotonin (5-HT) transporter (SERT) and the 5-HT2C receptor a novel series of 3-amino-1-phenylpropoxy substituted diphenylureas...
13.
α7 nicotinic acetylcholine receptors and their role in cognition
Lendvai B, Kassai F, Szajli A, Nemethy Z
Brain Res Bull . 2012 Nov; 93:86-96. PMID: 23178154
The precise role of nicotinic acetylcholine receptors (nAChRs) in central cognitive processes still remains incompletely understood almost 150 years after its initial discovery. Central nAChRs are activated by acetylcholine, which...
14.
Cariprazine (RGH-188), a dopamine D(3) receptor-preferring, D(3)/D(2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile
Kiss B, Horvath A, Nemethy Z, Schmidt E, Laszlovszky I, Bugovics G, et al.
J Pharmacol Exp Ther . 2010 Jan; 333(1):328-40. PMID: 20093397
Cariprazine {RGH-188; trans-N-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-N',N'-dimethylurea hydrochloride}, a novel candidate antipsychotic, demonstrated approximately 10-fold higher affinity for human D(3) versus human D(2L) and human D(2S) receptors (pKi 10.07, 9.16, and 9.31, respectively). It...
15.
Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in favourable antipsychotic-like activity in rodent models: I. neurochemical characterisation of RG-15
Kiss B, Laszlovszky I, Horvath A, Nemethy Z, Schmidt E, Bugovics G, et al.
Naunyn Schmiedebergs Arch Pharmacol . 2008 Jun; 378(5):515-28. PMID: 18551280
RG-15 (trans-N-[4-[2-[4-(3-cyano-5-trifluoromethyl-phenyl)-piperazine-1-yl]-ethyl]-cyclohexyl]-3-pyridinesulfonic amide dihydrochloride) displayed subnanomolar affinity to human and rat dopamine D3 receptors (pKi 10.49 and 9.42, respectively) and nanomolar affinity to human and rat D2 receptors (pKi 8.23...
16.
Application of the BD ACTOne technology for the high-throughput screening of Gs-coupled receptor antagonists
Visegrady A, Boros A, Nemethy Z, Kiss B, Keseru G
J Biomol Screen . 2007 Dec; 12(8):1068-73. PMID: 18087071
A novel technology for monitoring the changes of 3,'5'-adenosine cyclic monophosphate (cAMP) in live cells suitable for drug screening relies on the use of cyclic nucleotide-gated channels as biosensors coexpressed...