Zoya N Demidenko
Overview
Explore the profile of Zoya N Demidenko including associated specialties, affiliations and a list of published articles.
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39
Citations
2457
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Recent Articles
1.
Leontieva O, Demidenko Z, Blagosklonny M
Oncotarget
. 2015 Jul;
6(27):23238-48.
PMID: 26177051
In proliferating cells, mTOR is active and promotes cell growth. When the cell cycle is arrested, then mTOR converts reversible arrest to senescence (geroconversion). Rapamycin and other rapalogs suppress geroconversion,...
2.
McCubrey J, Steelman L, Bertrand F, Davis N, Sokolosky M, Abrams S, et al.
Oncotarget
. 2014 Jun;
5(10):2881-911.
PMID: 24931005
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular processes. Aberrant activity of...
3.
Leontieva O, Demidenko Z, Blagosklonny M
Proc Natl Acad Sci U S A
. 2014 Jun;
111(24):8832-7.
PMID: 24889617
During cell cycle arrest caused by contact inhibition (CI), cells do not undergo senescence, thus resuming proliferation after replating. The mechanism of senescence avoidance during CI is unknown. Recently, it...
4.
Leontieva O, Demidenko Z, Blagosklonny M
Cell Cycle
. 2013 Sep;
12(20):3249-52.
PMID: 24036549
Markers of cellular senescence depend in part on the MTOR (mechanistic target of rapamycin) pathway. MTOR participates in geroconversion, a conversion from reversible cell cycle arrest to irreversible senescence. Recently...
5.
Berman A, Leontieva O, Natarajan V, McCubrey J, Demidenko Z, Nikiforov M
Oncotarget
. 2013 Mar;
3(12):1522-32.
PMID: 23455653
It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the...
6.
McCubrey J, Steelman L, Chappell W, Sun L, Davis N, Abrams S, et al.
Oncotarget
. 2013 Mar;
3(12):1505-21.
PMID: 23455493
Over the past few years, significant advances have occurred in both our understanding of the complexity of signal transduction pathways as well as the isolation of specific inhibitors which target...
7.
McCubrey J, Demidenko Z
Aging (Albany NY)
. 2013 Feb;
4(12):887-93.
PMID: 23425920
The P53 gene and it product p53 protein is the most studied tumor suppressor, which was considered as oncogene for two decades until 1990. More than 60 thousand papers on...
8.
Leontieva O, Lenzo F, Demidenko Z, Blagosklonny M
Cell Cycle
. 2012 Nov;
11(24):4642-9.
PMID: 23187803
When the cell cycle is arrested, even though growth-promoting pathways such as mTOR are still active, then cells senesce. For example, induction of either p21 or p16 arrests the cell...
9.
Leontieva O, Natarajan V, Demidenko Z, Burdelya L, Gudkov A, Blagosklonny M
Proc Natl Acad Sci U S A
. 2012 Aug;
109(33):13314-8.
PMID: 22847439
Unlike reversible quiescence, cellular senescence is characterized by a large flat cell morphology, β-gal staining and irreversible loss of regenerative (i.e., replicative) potential. Conversion from proliferative arrest to irreversible senescence,...
10.
Demidenko Z, McCubrey J
Aging (Albany NY)
. 2012 Jan;
3(12):1154-62.
PMID: 22228887
In recent years, numerous new targets have been identified and new experimental therapeutics have been developed. Importantly, existing non-cancer drugs found novel use in cancer therapy. And even more importantly,...