Zoya N Demidenko
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Explore the profile of Zoya N Demidenko including associated specialties, affiliations and a list of published articles.
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39
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2457
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Recent Articles
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Leontieva O, Demidenko Z, Gudkov A, Blagosklonny M
PLoS One
. 2011 Oct;
6(10):e26126.
PMID: 22022534
Background: Depending on cellular context, p53-inducing agents (such as nutlin-3a) cause different outcomes including reversible quiescence and irreversible senescence. Inhibition of mTOR shifts the balance from senescence to quiescence. In...
14.
Demidenko Z, Blagosklonny M
Cell Cycle
. 2011 Apr;
10(10):1557-62.
PMID: 21521942
Prolyl hydroxylases (PHDs) target hypoxia-inducible factor-1α (HIF-1α) for degradation. Hypoxia inactivates PHDs, causing accumulation of HIF-1α. In turn, HIF-1 further transactivates PHDs. It is thought that the purpose of this...
15.
Apontes P, Leontieva O, Demidenko Z, Li F, Blagosklonny M
Oncotarget
. 2011 Mar;
2(3):222-33.
PMID: 21447859
Killing of proliferating normal cells limits chemotherapy of cancer. Several strategies to selectively protect normal cells were previously suggested. Here we further explored the protection of normal cells from cell...
16.
Korotchkina L, Leontieva O, Bukreeva E, Demidenko Z, Gudkov A, Blagosklonny M
Aging (Albany NY)
. 2010 Jul;
2(6):344-52.
PMID: 20606252
Transient induction of p53 can cause reversible quiescence and irreversible senescence. Using nutlin-3a (a small molecule that activates p53 without causing DNA damage), we have previously identified cell lines in...
17.
Demidenko Z, Korotchkina L, Gudkov A, Blagosklonny M
Proc Natl Acad Sci U S A
. 2010 May;
107(21):9660-4.
PMID: 20457898
The tumor suppressor p53 is a canonical inducer of cellular senescence (irreversible loss of proliferative potential and senescent morphology). p53 can also cause reversible arrest without senescent morphology, which has...
18.
Demidenko Z, Blagosklonny M
Aging (Albany NY)
. 2010 Feb;
1(12):1008-16.
PMID: 20157583
Development of agents that suppress aging (aging suppressants) requires quantification of cellular senescence. Cellular senescence in vitro is characterized by a large cell morphology and permanent loss of proliferative potential....
19.
Pospelova T, Demidenko Z, Bukreeva E, Pospelov V, Gudkov A, Blagosklonny M
Cell Cycle
. 2009 Dec;
8(24):4112-8.
PMID: 19946210
Cellular senescence is currently viewed as a response to DNA damage. In this report, we showed that non-damaging agents such as sodium butyrate-induced p21 and ectopic expression of either p21...
20.
Korotchkina L, Demidenko Z, Gudkov A, Blagosklonny M
Cell Cycle
. 2009 Oct;
8(22):3777-81.
PMID: 19855165
Cellular senescence is characterized by irreversible loss of proliferative potential and a large, flat cell morphology. Ectopic p21 and doxorubicin induced cellular senescence in HT1080 and WI-38-tert cell lines. In...