James A McCubrey
Overview
Explore the profile of James A McCubrey including associated specialties, affiliations and a list of published articles.
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Articles
307
Citations
10052
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Recent Articles
1.
McCubrey J, Follo M, Ratti S, Martelli A, Manzoli L, Augello G, et al.
Adv Biol Regul
. 2025 Jan;
95:101073.
PMID: 39809662
TP53 is normally a tumor suppressor. However, it is mutated in at least 50% of human cancers. Usually, we assume that mutation of the TP53 is associated with loss of...
2.
Ceneri E, De Stefano A, Casalin I, Finelli C, Curti A, Paolini S, et al.
Adv Biol Regul
. 2024 Dec;
95:101071.
PMID: 39648082
Key signaling pathways within the Bone Marrow Microenvironment (BMM), such as Notch, Phosphoinositide-Specific Phospholipase C (PI-PLCs), Transforming Growth Factor β (TGF-β), and Nuclear Factor Kappa B (NF-κB), play a vital...
3.
Lavoro A, Falzone L, Gattuso G, Conti G, Caltabiano R, Madonna G, et al.
J Transl Med
. 2024 Oct;
22(1):887.
PMID: 39358721
Background: Cancer onset and progression are driven by genetic and epigenetic alterations leading to oncogene activation and the silencing of tumor suppressor genes. Among epigenetic mechanisms, DNA methylation (methDNA) is...
4.
Fazio A, Neri I, Koufi F, Marvi M, Galvani A, Evangelisti C, et al.
Int J Mol Sci
. 2024 Jun;
25(12).
PMID: 38928298
Pericytes are multipotent cells embedded within the vascular system, primarily surrounding capillaries and microvessels where they closely interact with endothelial cells. These cells are known for their intriguing properties due...
5.
Cervello M, Augello G, Cocco L, Ratti S, Follo M, Martelli A, et al.
Adv Biol Regul
. 2024 May;
92:101032.
PMID: 38693042
Hepatocellular carcinoma (HCC) is a common cancer which unfortunately has poor outcomes. Common anti-cancer treatments such as chemotherapy and targeted therapy have not increased patient survival significantly. A common treatment...
6.
Casalin I, De Stefano A, Ceneri E, Cappellini A, Finelli C, Curti A, et al.
Adv Biol Regul
. 2024 Jan;
91:101014.
PMID: 38242820
Myelodysplastic Syndromes, a heterogeneous group of hematological disorders, are characterized by abnormalities in phosphoinositide-dependent signaling, epigenetic regulators, apoptosis, and cytokine interactions within the bone marrow microenvironment, contributing to disease pathogenesis...
7.
Marvi M, Neri I, Evangelisti C, Ramazzotti G, Asioli S, Zoli M, et al.
Biomolecules
. 2023 May;
13(5).
PMID: 37238668
Phospholipases are essential intermediaries that work as hydrolyzing enzymes of phospholipids (PLs), which represent the most abundant species contributing to the biological membranes of nervous cells of the healthy human...
8.
Mongiorgi S, De Stefano A, Ratti S, Indio V, Astolfi A, Casalin I, et al.
Clin Epigenetics
. 2023 Feb;
15(1):27.
PMID: 36803590
Background: miRNAs are small non-coding RNAs that regulate gene expression and are linked to cancer development and progression. miRNA profiles are currently studied as new prognostic factors or therapeutic perspectives....
9.
Martelli A, Paganelli F, Truocchio S, Palumbo C, Chiarini F, McCubrey J
Int J Mol Sci
. 2023 Feb;
24(3).
PMID: 36769284
The Hedgehog (HH) signaling network is one of the main regulators of invertebrate and vertebrate embryonic development. Along with other networks, such as NOTCH and WNT, HH signaling specifies both...
10.
De Stefano A, Marvi M, Fazio A, McCubrey J, Suh P, Ratti S, et al.
Adv Biol Regul
. 2023 Jan;
87:100955.
PMID: 36706610
Aberrant signaling pathways regulating proliferation and differentiation of hematopoietic stem cells (HSCs) can contribute to disease pathogenesis and neoplastic growth. Phosphoinositides (PIs) are inositol phospholipids that are implicated in the...