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Zi-Lin Zhang

Explore the profile of Zi-Lin Zhang including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 40
Followers 0
Related Specialties
Chemistry
Biochemistry
Cardiology & Vascular Diseases
Top 10 Co-Authors
Shuo-Bin Chen
Zhi-Shu Huang
Jia-Heng Tan
Tian-Miao Ou
Chen-Xi Wang
Jia-En Wang
Shi-Liang Huang
Jia-Li Tu
Hong-Gen Wang
Qi-Kun Yin
Published In
J Med Chem
Int J Biol Macromol
J Hypertens
Eur J Med Chem
Front Pharmacol
Affiliations
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Recent Articles
1.
Identification of sanguinarine as c-MYC transcription inhibitor through enhancing the G-quadruplex-NM23-H2 interactions
Zhong L, Yuan J, Fu W, Zhang Z, Li X, Ou T, et al.
Bioorg Chem . 2024 Sep; 153:107842. PMID: 39342890
c-MYC is a proto-oncogene ubiquitously overexpressed in various cancers. The formation of G-quadruplex (G4) structures within the c-MYC promoter region can regulate its transcription by interfering with protein binding. Consequently,...
2.
Design, synthesis and evaluation of N3-substituted quinazolinone derivatives as potential Bloom's Syndrome protein (BLM) helicase inhibitor for sensitization treatment of colorectal cancer
Tu J, Wu B, Wu H, Wang J, Zhang Z, Gao K, et al.
Eur J Med Chem . 2022 Dec; 246:114944. PMID: 36459756
The homologous recombination repair (HRR) pathway is critical for repairing double-strand breaks (DSB). Inhibition of the HRR pathway is usually considered a promising strategy for anticancer therapy. The Bloom's Syndrome...
3.
Pea pod-mimicking hydroxyapatite nanowhisker-reinforced poly(lactic acid) composites with bone-like strength
Xu H, Ke L, Tang M, Shang H, Zhang Z, Xu W, et al.
Int J Biol Macromol . 2022 Jul; 216:114-123. PMID: 35793741
The anisotropic hierarchical structures of naturally derived materials have offered useful design principles for the fabrication of high-strength and functional materials. Herein, we unraveled a structure-by-bionics approach to construction of...
4.
Chinese Patent Medicine Liuweiwuling Tablet had Potent Inhibitory Effects on Both Wild-Type and Entecavir-Resistant Hepatitis B Virus (HBV) and Effectively Suppressed HBV Replication in Mouse Model
Ge F, Si L, Yang Y, Li Y, Lv Z, Liu W, et al.
Front Pharmacol . 2021 Nov; 12:756975. PMID: 34776974
Liuweiwuling Tablet (LWWL) is a licensed Chinese patent medicine (approval number: Z20060238) included in the national health insurance for anti-inflammation of chronic HBV infection, whereas its anti-HBV effect remains clarification....
5.
Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors
Wang C, Zhang Z, Yin Q, Tu J, Wang J, Xu Y, et al.
J Med Chem . 2020 Jul; 63(17):9752-9772. PMID: 32697083
DNA damage response (DDR) pathways are crucial for the survival of cancer cells and are attractive targets for cancer therapy. Bloom syndrome protein (BLM) is a DNA helicase that performs...
6.
Cannabinoid type 2 receptor agonist JWH133 decreases blood pressure of spontaneously hypertensive rats through relieving inflammation in the rostral ventrolateral medulla of the brain
Shi H, Guo H, Liu H, Zhang Z, Hu M, Zhang Y, et al.
J Hypertens . 2020 Apr; 38(5):886-895. PMID: 32238784
Objective: Neuroinflammation in the rostral ventrolateral medulla (RVLM) has been reported to be associated with hypertension. The upregulation and activation of the cannabinoid type 2 (CB2) receptor may be part...
7.
Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair
Yin Q, Wang C, Wang Y, Guo Q, Zhang Z, Ou T, et al.
J Med Chem . 2019 Mar; 62(6):3147-3162. PMID: 30827110
Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3'-5' DNA...