Zhao-Qing Shen
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Explore the profile of Zhao-Qing Shen including associated specialties, affiliations and a list of published articles.
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19
Citations
245
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Recent Articles
1.
Wu I, Liao Y, Tsai T, Lin C, Shen Z, Chan Y, et al.
Gut Microbes
. 2025 Mar;
17(1):2473506.
PMID: 40050256
Diabetic kidney disease (DKD) is a serious healthcare dilemma. Nonetheless, the interplay between the functional capacity of gut microbiota and their host remains elusive for DKD. This study aims to...
2.
Transcriptomic predictors of rapid progression from mild cognitive impairment to Alzheimer's disease
Huang Y, Tsai T, Shen Z, Chan Y, Tu C, Tung C, et al.
Alzheimers Res Ther
. 2025 Jan;
17(1):3.
PMID: 39754267
Background: Effective treatment for Alzheimer's disease (AD) remains an unmet need. Thus, identifying patients with mild cognitive impairment (MCI) who are at high-risk of progressing to AD is crucial for...
3.
Shen Z, Chang C, Yeh C, Lu C, Hung H, Wang T, et al.
J Biomed Sci
. 2024 Jan;
31(1):15.
PMID: 38263133
Background: CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene, mediates healthspan in mammals. CISD2 is down-regulated during aging. Furthermore, a persistently high level of CISD2 promotes longevity and ameliorates...
4.
Yao C, Shen Z, Rajan Y, Huang Y, Lin C, Song J, et al.
Eur J Med Chem
. 2023 Jul;
258:115583.
PMID: 37393792
Down-regulation of Cisd2 in the liver has been implicated in the development of nonalcoholic fatty liver disease (NAFLD) and increasing the level of Cisd2 is therefore a potential therapeutic approach...
5.
Sun C, Lee S, Chen L, Lai C, Shen Z, Chen N, et al.
Cell Signal
. 2023 Jun;
109:110755.
PMID: 37315750
Chronic epithelial defects of the cornea, which are usually associated with severe dry eye disease, diabetes mellitus, chemical injuries or neurotrophic keratitis, as well as aging, are an unmet clinical...
6.
Yeh C, Shen Z, Lin C, Lu C, Tsai T
Int J Mol Sci
. 2022 Nov;
23(22).
PMID: 36430496
The aging human population with age-associated diseases has become a problem worldwide. By 2050, the global population of those who are aged 65 years and older will have tripled. In...
7.
Yeh C, Shen Z, Wang T, Kao C, Teng Y, Yeh T, et al.
J Biomed Sci
. 2022 Jul;
29(1):53.
PMID: 35871686
Background: The human CISD2 gene is located within a longevity region mapped on chromosome 4q. In mice, Cisd2 levels decrease during natural aging and genetic studies have shown that a...
8.
Huang Y, Shen Z, Tsai T
Aging (Albany NY)
. 2022 Mar;
14(4):1594-1596.
PMID: 35247253
No abstract available.
9.
Huang Y, Shen Z, Huang C, Lin C, Tsai T
Aging Cell
. 2021 Nov;
20(12):e13523.
PMID: 34811857
The liver plays a pivotal role in mammalian aging. However, the mechanisms underlying liver aging remain unclear. Cisd2 is a pro-longevity gene in mice. Cisd2 mediates lifespan and healthspan via...
10.
Sun C, Lee S, Kao C, Chen L, Shen Z, Lai C, et al.
EBioMedicine
. 2021 Nov;
73:103654.
PMID: 34740104
Background: Age-related changes affecting the ocular surface cause vision loss in the elderly. Cisd2 deficiency drives premature aging in mice as well as resulting in various ocular surface abnormalities. Here...