Zeynep Betts
Overview
Explore the profile of Zeynep Betts including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
32
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Recent Articles
1.
Alimudin J, Betts Z, Deveci Ozkan A
Biomedicines
. 2025 Feb;
13(2).
PMID: 40002709
: Sodium butyrate (NaBu), a short-chain fatty acid, modulates global gene expression through histone deacetylase (HDAC) inhibition, suppressing proliferation and inducing apoptosis in various cancers. Rutin (RUT), a polyphenolic flavonoid...
2.
Betts Z, Deveci Ozkan A, Yuksel B, Alimudin J, Aydin D, Aksoy O, et al.
J Toxicol Environ Health A
. 2023 Sep;
86(22):833-845.
PMID: 37668343
Quercetin (QUE) belonging to the flavonoid class is a common phytochemical present in the daily diet of some individuals. Quercetin is an important source of free radical scavengers. This property...
3.
Torres M, Betts Z, Scholey R, Elvin M, Place S, Hayes A, et al.
Biotechnol Bioeng
. 2023 Apr;
120(9):2389-2402.
PMID: 37060548
Phenotypic stability of Chinese hamster ovary (CHO) cells over long term culture (LTC) presents one of the most pressing challenges in the development of therapeutic protein manufacturing processess. However, our...
4.
Deveci Ozkan A, Alimudin J, Kilciler Y, Yuksel B, Aksoy O, Betts Z
Int J Environ Health Res
. 2022 Sep;
33(12):1728-1737.
PMID: 36122174
Developing new drugs from natural products is important for therapeutic effects to minimise tissue toxicity of drugs used in cancer treatment. Eisenia foetida is a worm with a double transport...
5.
Yuksel B, Deveci Ozkan A, Aydin D, Betts Z
Saudi J Biol Sci
. 2022 Mar;
29(3):1394-1401.
PMID: 35280546
Oncogenic stimulation shows a rise in reactive oxygen species (ROS), and ROS can eventually induce carcinogenesis by causing DNA damage. In this context, this study aims to evaluate some biochemical...
6.
Torres M, Elvin M, Betts Z, Place S, Gaffney C, Dickson A
Biotechnol Prog
. 2020 Nov;
37(2):e3099.
PMID: 33169492
Culture systems based on spin tube reactors have been consolidated in the development of manufacturing processes based on Chinese hamster ovary (CHO) cells. Despite their widespread use, there is little...
7.
Betts Z, Dickson A
Methods Mol Biol
. 2017 May;
1603:119-141.
PMID: 28493127
Therapeutic proteins require proper folding and posttranslational modifications to be effective and biologically active. Chinese hamster ovary (CHO) cells are by far the most frequently used host for commercial production...
8.
Betts Z, Dickson A
Biotechnol J
. 2015 Dec;
11(4):554-64.
PMID: 26632501
The requirement for complex therapeutic proteins has resulted in mammalian cells, especially CHO cells, being the dominant host for recombinant protein manufacturing. In creating recombinant CHO cell lines, the expression...
9.
Betts Z, Dickson A
Mol Biotechnol
. 2015 Jun;
57(9):846-58.
PMID: 26088164
CHO cells are the most frequently used host for commercial production of therapeutic proteins, and DHFR-mediated gene amplification is extensively applied to generate cell lines with increased protein production. However,...
10.
Betts Z, Croxford A, Dickson A
Biotechnol Prog
. 2015 Apr;
31(4):1014-25.
PMID: 25829363
Chinese hamster ovary (CHO) cells are widely used in the biopharmaceutical industry. In the creation of mammalian cell lines plasmid DNA carrying the gene-of-interest integrates randomly into the host cell...