Zahra Shirzadi
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Explore the profile of Zahra Shirzadi including associated specialties, affiliations and a list of published articles.
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35
Citations
394
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Recent Articles
1.
Coughlan G, Klinger H, Boyle R, Betthauser T, Binette A, Christenson L, et al.
JAMA Neurol
. 2025 Mar;
PMID: 40029638
Importance: Alzheimer disease (AD) predominates in females at almost twice the rate relative to males. Mounting evidence in adults without AD indicates that females exhibit higher tau deposition than age-matched...
2.
Schultz S, Liu L, Schultz A, Fitzpatrick C, Levin R, Bellier J, et al.
Lancet Neurol
. 2024 Jul;
23(9):913-924.
PMID: 39074479
Background: Genetic variants that cause autosomal dominant Alzheimer's disease are highly penetrant but vary substantially regarding age at symptom onset (AAO), rates of cognitive decline, and biomarker changes. Most pathogenic...
3.
Boyle R, Townsend D, Klinger H, Scanlon C, Yuan Z, Coughlan G, et al.
Alzheimers Res Ther
. 2024 Jul;
16(1):148.
PMID: 38961512
Background: Leveraging Alzheimer's disease (AD) imaging biomarkers and longitudinal cognitive data may allow us to establish evidence of cognitive resilience (CR) to AD pathology in-vivo. Here, we applied latent class...
4.
5.
Vascular contributions to cognitive decline: Beyond amyloid and tau in the Harvard Aging Brain Study
Shirzadi Z, Boyle R, Yau W, Coughlan G, Fu J, Properzi M, et al.
J Cereb Blood Flow Metab
. 2024 Mar;
44(8):1319-1328.
PMID: 38452039
In addition to amyloid and tau pathology, elevated systemic vascular risk, white matter injury, and reduced cerebral blood flow contribute to late-life cognitive decline. Given the strong collinearity among these...
6.
Joseph-Mathurin N, Feldman R, Lu R, Shirzadi Z, Toomer C, Saint Clair J, et al.
Alzheimers Dement
. 2024 Feb;
20(4):2680-2697.
PMID: 38380882
Introduction: Amyloidosis, including cerebral amyloid angiopathy, and markers of small vessel disease (SVD) vary across dominantly inherited Alzheimer's disease (DIAD) presenilin-1 (PSEN1) mutation carriers. We investigated how mutation position relative...
7.
Yang H, Yau W, Carlyle B, Trombetta B, Zhang C, Shirzadi Z, et al.
Brain
. 2024 Feb;
147(6):2158-2168.
PMID: 38315899
Vascular dysfunction is increasingly recognized as an important contributor to the pathogenesis of Alzheimer's disease. Alterations in vascular endothelial growth factor (VEGF) pathways have been implicated as potential mechanisms. However,...
8.
Shirzadi Z, Schultz S, Yau W, Joseph-Mathurin N, Fitzpatrick C, Levin R, et al.
JAMA Neurol
. 2023 Oct;
80(12):1353-1363.
PMID: 37843849
Importance: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains...
9.
Schultz S, Shirzadi Z, Schultz A, Liu L, Fitzpatrick C, McDade E, et al.
Aging Cell
. 2023 Jun;
22(8):e13871.
PMID: 37291760
Although pathogenic variants in PSEN1 leading to autosomal-dominant Alzheimer disease (ADAD) are highly penetrant, substantial interindividual variability in the rates of cognitive decline and biomarker change are observed in ADAD....
10.
Koemans E, Chhatwal J, van Veluw S, van Etten E, van Osch M, van Walderveen M, et al.
Lancet Neurol
. 2023 May;
22(7):632-642.
PMID: 37236210
Cerebral amyloid angiopathy, which is defined by cerebrovascular deposition of amyloid β, is a common age-related small vessel pathology associated with intracerebral haemorrhage and cognitive impairment. Based on complementary lines...