Zahra Rattray
Overview
Explore the profile of Zahra Rattray including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
191
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Recent Articles
1.
Lodge J, Kajtar L, Duxbury R, Hall D, Burley G, Cordy J, et al.
MAbs
. 2025 Feb;
17(1):2459795.
PMID: 39957177
The binding kinetics of an antibody for its target antigen represent key determinants of its biological function and success as a novel biotherapeutic. Defining these interactions and kinetics is critical...
2.
Roamcharern N, Matthew S, Brady D, Parkinson J, Rattray Z, Seib F
ACS Biomater Sci Eng
. 2025 Jan;
11(3):1847-1856.
PMID: 39883858
Silk has emerged as an interesting candidate among protein-based nanocarriers due to its favorable properties, including biocompatibility and a broad spectrum of processing options to tune particle critical quality attributes....
3.
Abdulrahman R, Punnabhum P, Capomaccio R, Treacher K, Perrie Y, Rattray Z
J Chromatogr A
. 2025 Jan;
1743:465663.
PMID: 39826279
Research into nanoparticle interactions with biomolecules has become increasingly important in nanomedicine. While lipid nanoparticles (LNPs) are widely used as drug delivery systems, there remains a gap in understanding their...
4.
Armstrong G, Roche A, Lewis W, Rattray Z
MAbs
. 2024 Dec;
16(1):2438172.
PMID: 39663541
Monoclonal antibody (mAb) solution viscosity in ultra-high concentration formulations is a key developability consideration in mAb development risk mitigation strategies that has implications for downstream processing and patient safety. Predicting...
5.
Al Sultan A, Rattray Z, Rattray N
Metabolomics
. 2024 Dec;
21(1):1.
PMID: 39636558
Introduction: Despite the well-established efficacy of thiazolidinediones (TZDs), including pioglitazone and rosiglitazone, in type II diabetes management, their potential contribution to heart failure risk remains a significant area of uncertainty....
6.
Binici B, Rattray Z, Zinger A, Perrie Y
J Control Release
. 2024 Nov;
377:162-173.
PMID: 39521063
Ionizable lipids are widely recognized as the crucial component of lipid nanoparticles (LNPs). They enable mRNA encapsulation, shield it from enzymatic degradation, facilitate cellular uptake, and foster its cytosolic release...
7.
Armstrong G, Burley G, Lewis W, Rattray Z
Mol Pharm
. 2024 Nov;
21(12):6423-6432.
PMID: 39509699
Early-phase manufacturability assessment of high-concentration therapeutic monoclonal antibodies (mAbs) involves screening of process-related risks impacting their translation into the clinic. Manufacturing a mAb at scale relies on cost-effective and robust...
8.
McMillan C, Druschitz A, Rumbelow S, Borah A, Binici B, Rattray Z, et al.
RSC Pharm
. 2024 Sep;
1(4):841-853.
PMID: 39323767
Lipid nanoparticles (LNPs), most commonly recognised for their role in COVID-19 mRNA vaccines, are important delivery vehicles for nucleic acid (mRNA, siRNA) therapies. The physicochemical attributes, such as size, nucleic...
9.
Cunningham M, Rattray N, McFadden Y, Berardi D, Daramy K, Kelly P, et al.
Int J Pharm Pract
. 2024 Sep;
32(6):515-523.
PMID: 39305489
Objectives: Breast cancer remains a prevalent disease in women worldwide. Though advancements in breast cancer care have improved patient survival, a breast cancer diagnosis, and subsequent interventions have a lasting...
10.
Armstrong G, Lewis A, Shah V, Taylor P, Jamieson C, Burley G, et al.
ACS Pharmacol Transl Sci
. 2024 Aug;
7(8):2439-2451.
PMID: 39144567
Immunoglobulin G 3 (IgG3) monoclonal antibodies (mAbs) are high-value scaffolds for developing novel therapies. Despite their wide-ranging therapeutic potential, IgG3 physicochemical properties and developability characteristics remain largely under-characterized. Protein-protein interactions...