Glenn A Burley
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Explore the profile of Glenn A Burley including associated specialties, affiliations and a list of published articles.
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90
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668
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Recent Articles
1.
Lodge J, Kajtar L, Duxbury R, Hall D, Burley G, Cordy J, et al.
MAbs
. 2025 Feb;
17(1):2459795.
PMID: 39957177
The binding kinetics of an antibody for its target antigen represent key determinants of its biological function and success as a novel biotherapeutic. Defining these interactions and kinetics is critical...
2.
Stevens R, Palmer H, Miah A, Burley G
J Org Chem
. 2025 Feb;
90(6):2192-2200.
PMID: 39895090
Ultra high-throughput chemistry carried out in 1536-well plates is increasingly utilized for reaction optimization protocols and direct-to-biology (D2B) platforms, where nanomolar quantities of the final product are directly assessed for...
3.
Stevens R, Shrives H, Cryan J, Klimaszewska D, Stacey P, Burley G, et al.
RSC Med Chem
. 2024 Dec;
PMID: 39720740
High-throughput chemistry (HTC) and direct-to-biology (D2B) platforms allow for plate-based compound synthesis and biological evaluation of crude mixtures in cellular assays. The rise of these workflows has rapidly accelerated drug-discovery...
4.
Salihovic A, Ascham A, Rosenqvist P, Taladriz-Sender A, Hoskisson P, Hodgson D, et al.
Chem Sci
. 2024 Dec;
16(3):1302-1307.
PMID: 39691463
Ribonucleosides are essential building blocks used extensively in antiviral and oligonucleotide therapeutics. A major challenge in the further development of nucleoside analogues for therapeutic applications is access to scalable and...
5.
Halford-McGuff J, Richardson T, McKay A, Peschke F, Burley G, Watson A
Beilstein J Org Chem
. 2024 Dec;
20:3198-3204.
PMID: 39669442
We report the synthesis of germanyl triazoles formed via a copper-catalysed azide-alkyne cycloaddition (CuAAC) of germanyl alkynes. The reaction is often high yielding, functional group tolerant, and compatible with complex...
6.
Armstrong G, Burley G, Lewis W, Rattray Z
Mol Pharm
. 2024 Nov;
21(12):6423-6432.
PMID: 39509699
Early-phase manufacturability assessment of high-concentration therapeutic monoclonal antibodies (mAbs) involves screening of process-related risks impacting their translation into the clinic. Manufacturing a mAb at scale relies on cost-effective and robust...
7.
Hryczanek H, Barrett J, Barrett T, Burley G, Cookson R, Hatley R, et al.
J Med Chem
. 2024 Oct;
67(21):19689-19715.
PMID: 39417301
The αβ integrin has been identified as a target for the treatment of fibrotic diseases, based on the role it has in activating TGF-β, a protein implicated in the pathogenesis...
8.
Peschke F, Taladriz-Sender A, Watson A, Burley G
Bioconjug Chem
. 2024 Oct;
35(11):1788-1796.
PMID: 39385696
The Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a key ligation tool used to prepare bioconjugates. Despite the widespread utility of CuAAC to produce discrete 1,4-triazole products, the requirement of a...
9.
Salihovic A, Ascham A, Taladriz-Sender A, Bryson S, Withers J, McKean I, et al.
Chem Sci
. 2024 Sep;
PMID: 39234214
Nucleosides are pervasive building blocks that are found throughout nature and used extensively in medicinal chemistry and biotechnology. However, the preparation of base-modified analogues using conventional synthetic methodology poses challenges...
10.
Armstrong G, Lewis A, Shah V, Taylor P, Jamieson C, Burley G, et al.
ACS Pharmacol Transl Sci
. 2024 Aug;
7(8):2439-2451.
PMID: 39144567
Immunoglobulin G 3 (IgG3) monoclonal antibodies (mAbs) are high-value scaffolds for developing novel therapies. Despite their wide-ranging therapeutic potential, IgG3 physicochemical properties and developability characteristics remain largely under-characterized. Protein-protein interactions...