Zachary T Schug
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Explore the profile of Zachary T Schug including associated specialties, affiliations and a list of published articles.
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41
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2472
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Recent Articles
1.
Hlavaty S, Salcido K, Pniewski K, Mukha D, Ma W, Kannan T, et al.
Cell Rep
. 2024 Nov;
43(12):114988.
PMID: 39579354
Cancer cells often use alternative nutrient sources to support their metabolism and proliferation. One important alternative nutrient source for many cancers is acetate. Acetate is metabolized into acetyl-coenzyme A (CoA)...
2.
Mukha D, Dessain J, OConnor S, Pniewski K, Bertolazzi F, Patel J, et al.
bioRxiv
. 2024 May;
PMID: 38766222
Proliferating cancer cells actively utilize anabolic processes for biomass production, including biosynthesis of amino acids, nucleotides, and fatty acids. The key enzyme of the fatty acid biosynthesis pathway, fatty acid...
3.
Miller K, OConnor S, Pniewski K, Kannan T, Acosta R, Mirji G, et al.
Nat Cancer
. 2023 Sep;
4(10):1491-1507.
PMID: 37723305
Acetate metabolism is an important metabolic pathway in many cancers and is controlled by acetyl-CoA synthetase 2 (ACSS2), an enzyme that catalyzes the conversion of acetate to acetyl-CoA. While the...
4.
Han A, Mukha D, Chua V, Purwin T, Tiago M, Modasia B, et al.
Cancers (Basel)
. 2023 Jul;
15(13).
PMID: 37444561
Uveal melanoma (UM) displays a high frequency of metastasis; however, effective therapies for metastatic UM are limited. Identifying unique metabolic features of UM may provide a potential targeting strategy. A...
5.
Siegel S, Brooks M, Berman J, Lynch S, Sims-Mourtada J, Schug Z, et al.
Cancer Med
. 2023 Mar;
12(10):11760-11772.
PMID: 36916687
Background: Despite similar incidence rates among Black and White women, breast cancer mortality rates are 40% higher among Black women. More than half of the racial difference in breast cancer...
6.
Fu S, Deng H, Bertolini I, Perego M, Chen E, Sanseviero E, et al.
Cancer Immunol Res
. 2022 Dec;
11(3):278-289.
PMID: 36548516
Pathologically activated neutrophils (PMN) with immunosuppressive activity, which are termed myeloid-derived suppressor cells (PMN-MDSC), play a critical role in regulating tumor progression. These cells have been implicated in promoting tumor...
7.
Siegel S, Brooks M, Lynch S, Sims-Mourtada J, Schug Z, Curriero F
Breast Cancer Res
. 2022 Jun;
24(1):37.
PMID: 35650633
Background: Triple negative breast cancer (TNBC) is an aggressive subtype of invasive breast cancer that disproportionately affects Black women and contributes to racial disparities in breast cancer mortality. Prior research...
8.
Mukha D, Fokra M, Feldman A, Sarvin B, Sarvin N, Nevo-Dinur K, et al.
Cell Metab
. 2022 May;
34(5):775-782.e9.
PMID: 35508111
The folic acid cycle mediates the transfer of one-carbon (1C) units to support nucleotide biosynthesis. While the importance of serine as a mitochondrial and cytosolic donor of folate-mediated 1C units...
9.
Han A, Chua V, Baqai U, Purwin T, Bechtel N, Hunter E, et al.
Oncogene
. 2022 Jan;
41(8):1129-1139.
PMID: 35046531
Effective therapeutic options are still lacking for uveal melanoma (UM) patients who develop metastasis. Metastatic traits of UM are linked to BRCA1-associated protein 1 (BAP1) mutations. Cell metabolism is re-programmed...
10.
Stine Z, Schug Z, Salvino J, Dang C
Nat Rev Drug Discov
. 2021 Dec;
21(2):141-162.
PMID: 34862480
One hundred years have passed since Warburg discovered alterations in cancer metabolism, more than 70 years since Sidney Farber introduced anti-folates that transformed the treatment of childhood leukaemia, and 20...