Zachary J Heins
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Explore the profile of Zachary J Heins including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
2520
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Recent Articles
1.
Garcia-Ruano D, Jain A, Heins Z, Wong B, Yimer Wolle E, Khalil A, et al.
Open Biol
. 2023 Jul;
13(7):230118.
PMID: 37491941
Experimental evolution using fast-growing unicellular organisms is a unique strategy for deciphering the principles and mechanisms underlying evolutionary processes as well as the architecture and wiring of basic biological functions....
2.
Molina R, Rix G, Mengiste A, Alvarez B, Seo D, Chen H, et al.
Nat Rev Methods Primers
. 2023 Apr;
2.
PMID: 37073402
No abstract available.
3.
Garcia-Ruano D, Jain A, Heins Z, Wong B, Yimer Wolle E, Khalil A, et al.
bioRxiv
. 2023 Apr;
PMID: 37034650
Experimental evolution using fast-growing unicellular organisms is a unique strategy for deciphering the principles and mechanisms underlying evolutionary processes as well as the architecture and wiring of basic biological functions....
4.
Huang T, Heins Z, Miller S, Wong B, Balivada P, Wang T, et al.
Nat Biotechnol
. 2022 Sep;
41(1):96-107.
PMID: 36076084
Despite the availability of Cas9 variants with varied protospacer-adjacent motif (PAM) compatibilities, some genomic loci-especially those with pyrimidine-rich PAM sequences-remain inaccessible by high-activity Cas9 proteins. Moreover, broadening PAM sequence compatibility...
5.
Wu P, Heins Z, Muller J, Katsnelson L, de Bruijn I, Abeshouse A, et al.
Mol Cell Proteomics
. 2019 Jul;
18(9):1893-1898.
PMID: 31308250
The Clinical Proteomic Tumor Analysis Consortium (CPTAC) has produced extensive mass spectrometry-based proteomics data for selected breast, colon, and ovarian tumors from The Cancer Genome Atlas (TCGA). We have incorporated...
6.
Heins Z, Mancuso C, Kiriakov S, Wong B, Bashor C, Khalil A
J Vis Exp
. 2019 Jun;
(147).
PMID: 31157778
Continuous culture methods enable cells to be grown under quantitatively controlled environmental conditions, and are thus broadly useful for measuring fitness phenotypes and improving our understanding of how genotypes are...
7.
Janjigian Y, Sanchez-Vega F, Jonsson P, Chatila W, Hechtman J, Ku G, et al.
Cancer Discov
. 2017 Nov;
8(1):49-58.
PMID: 29122777
The incidence of esophagogastric cancer is rapidly rising, but only a minority of patients derive durable benefit from current therapies. Chemotherapy as well as anti-HER2 and PD-1 antibodies are standard...
8.
Abida W, Armenia J, Gopalan A, Brennan R, Walsh M, Barron D, et al.
JCO Precis Oncol
. 2017 Aug;
2017.
PMID: 28825054
Purpose: A long natural history and a predominant osseous pattern of metastatic spread are impediments to the adoption of precision medicine in patients with prostate cancer. To establish the feasibility...
9.
Zehir A, Benayed R, Shah R, Syed A, Middha S, Kim H, et al.
Nat Med
. 2017 Aug;
23(8):1004.
PMID: 28777785
No abstract available.
10.
Zehir A, Benayed R, Shah R, Syed A, Middha S, Kim H, et al.
Nat Med
. 2017 May;
23(6):703-713.
PMID: 28481359
Tumor molecular profiling is a fundamental component of precision oncology, enabling the identification of genomic alterations in genes and pathways that can be targeted therapeutically. The existence of recurrent targetable...