Yvette C Wong
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Explore the profile of Yvette C Wong including associated specialties, affiliations and a list of published articles.
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3031
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Recent Articles
1.
Coscia S, Moore A, Wong Y, Holzbaur E
Curr Opin Cell Biol
. 2024 May;
88:102364.
PMID: 38692079
First identified in dividing cells as revolving clusters of actin filaments, these are now understood as mitochondrially-associated actin waves that are active throughout the cell cycle. These waves are formed...
2.
Schrder L, Peng W, Gao G, Wong Y, Schwake M, Krainc D
J Cell Biol
. 2024 Feb;
223(5).
PMID: 38358348
Loss-of-function mutations in VPS13C are linked to early-onset Parkinson's disease (PD). While VPS13C has been previously studied in non-neuronal cells, the neuronal role of VPS13C in disease-relevant human dopaminergic neurons...
3.
Leisten E, Woods A, Wong Y
J Cell Biol
. 2023 Nov;
222(12).
PMID: 37917024
Live super-resolution microscopy has allowed for new insights into recently identified mitochondria-lysosome contact sites, which mediate crosstalk between mitochondria and lysosomes, including co-regulation of Rab7 GTP hydrolysis and Drp1 GTP...
4.
Wong Y, Jayaraj N, Belton T, Shum G, Ball H, Ren D, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(44):e2313010120.
PMID: 37878717
Inter-organelle contact sites between mitochondria and lysosomes mediate the crosstalk and bidirectional regulation of their dynamics in health and disease. However, mitochondria-lysosome contact sites and their misregulation have not been...
5.
Song P, Peng W, Sauve V, Fakih R, Xie Z, Ysselstein D, et al.
Neuron
. 2023 Sep;
111(23):3775-3788.e7.
PMID: 37716354
Parkin-mediated mitophagy has been studied extensively, but whether mutations in parkin contribute to Parkinson's disease pathogenesis through alternative mechanisms remains unexplored. Using patient-derived dopaminergic neurons, we found that phosphorylation of...
6.
Peng W, Schroder L, Song P, Wong Y, Krainc D
Sci Adv
. 2023 Jul;
9(29):eadh3347.
PMID: 37467322
Mutations in the E3 ubiquitin ligase parkin are the most common cause of early-onset Parkinson's disease (PD). Although parkin modulates mitochondrial and endolysosomal homeostasis during cellular stress, whether parkin regulates...
7.
Chen Y, Quan S, Patil V, Kunjamma R, Tokars H, Leisten E, et al.
Glia
. 2023 May;
71(9):2180-2195.
PMID: 37203250
central nervous system (CNS) inflammation triggers activation of the integrated stress response (ISR). We previously reported that prolonging the ISR protects remyelinating oligodendrocytes and promotes remyelination in the presence of...
8.
Wong Y, Kim S, Cisneros J, Molakal C, Song P, Lubbe S, et al.
J Cell Biol
. 2022 Aug;
221(10).
PMID: 36044022
Lysosomes are highly dynamic organelles implicated in multiple diseases. Using live super-resolution microscopy, we found that lysosomal tethering events rarely undergo lysosomal fusion, but rather untether over time to reorganize...
9.
Belton T, Leisten E, Cisneros J, Wong Y
STAR Protoc
. 2022 Mar;
3(2):101262.
PMID: 35330964
Mitochondria-lysosome contact sites are critical for maintaining cellular homeostasis by regulating mitochondrial and lysosomal network dynamics and mediating metabolite exchange. Here, we present a protocol to quantitatively analyze the formation...
10.
Cisneros J, Belton T, Shum G, Molakal C, Wong Y
Trends Neurosci
. 2022 Mar;
45(4):312-322.
PMID: 35249745
Neurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as...