Mitochondria-lysosome Contact Site Dynamics and Misregulation in Neurodegenerative Diseases

Overview

Journal Trends Neurosci

Specialty Neurology

Date 2022 Mar 7

PMID 35249745

Authors

Jasmine Cisneros

Tayler B Belton

George C Shum

Catherine G Molakal

Yvette C Wong

Affiliations

Soon will be listed here.

Abstract

Neurons rely heavily on properly regulated mitochondrial and lysosomal homeostasis, with multiple neurodegenerative diseases linked to dysfunction in these two organelles. Interestingly, mitochondria-lysosome membrane contact sites have been identified as a key pathway mediating their crosstalk in neurons. Recent studies have further elucidated the regulation of mitochondria-lysosome contact dynamics via distinct tethering/untethering protein machinery. Moreover, this pathway has been shown to have additional functions in regulating organelle network dynamics and metabolite transfer between lysosomes and mitochondria. In this review, we highlight recent advances in the field of mitochondria-lysosome contact sites and their misregulation across multiple neurodegenerative disorders, which further underscore a potential role for this pathway in neuronal homeostasis and disease.

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