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» Authors » Yusuke Takeshima

Yusuke Takeshima

Explore the profile of Yusuke Takeshima including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 21
Citations 496
Followers 0
Related Specialties
Rheumatology
Allergy & Immunology
General Medicine
Top 10 Co-Authors
Yukiko Iwasaki
Keishi Fujio
Kazuhiko Yamamoto
Tomohisa Okamura
Yasuo Nagafuchi
Mineto Ota
Hirofumi Shoda
Shuji Sumitomo
Mai Okubo
Hiroaki Hatano
Published In
J Autoimmun
Rheumatology (Oxford)
Cell
Ann Rheum Dis
Biochem Biophys Res Commun
Affiliations
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Recent Articles
1.
Methylglyoxal compromises callus mineralization and impairs fracture healing through suppression of osteoblast terminal differentiation
Seto T, Yukata K, Tsuji S, Takeshima Y, Honda T, Sakamoto A, et al.
Biochem Biophys Res Commun . 2025 Jan; 747():151312. PMID: 39799866
Impaired fracture healing in diabetic patients leads to prolonged morbidity and increased healthcare costs. Methylglyoxal (MG), a reactive metabolite elevated in diabetes, is implicated in various complications, but its direct...
2.
Single-cell transcriptome landscape of circulating CD4 T cell populations in autoimmune diseases
Yasumizu Y, Takeuchi D, Morimoto R, Takeshima Y, Okuno T, Kinoshita M, et al.
Cell Genom . 2024 Feb; 4(2):100473. PMID: 38359792
CD4 T cells are key mediators of various autoimmune diseases; however, their role in disease progression remains unclear due to cellular heterogeneity. Here, we evaluated CD4 T cell subpopulations using...
3.
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity
Edahiro R, Shirai Y, Takeshima Y, Sakakibara S, Yamaguchi Y, Murakami T, et al.
Nat Genet . 2023 Apr; 55(5):753-767. PMID: 37095364
Mechanisms underpinning the dysfunctional immune response in severe acute respiratory syndrome coronavirus 2 infection are elusive. We analyzed single-cell transcriptomes and T and B cell receptors (BCR) of >895,000 peripheral...
4.
Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance
Yamada S, Nagafuchi Y, Wang M, Ota M, Hatano H, Takeshima Y, et al.
Ann Rheum Dis . 2023 Mar; 82(6):809-819. PMID: 36918189
Objectives: Little is known about the immunology underlying variable treatment response in rheumatoid arthritis (RA). We performed large-scale transcriptome analyses of peripheral blood immune cell subsets to identify immune cells...
5.
Transcriptome Profiling of Immune Cell Types in Peripheral Blood Reveals Common and Specific Pathways Involved in the Pathogenesis of Myositis-Specific Antibody-Positive Inflammatory Myopathies
Sugimori Y, Iwasaki Y, Takeshima Y, Okubo M, Kobayashi S, Hatano H, et al.
ACR Open Rheumatol . 2023 Jan; 5(2):93-102. PMID: 36651871
Objective: Idiopathic inflammatory myopathies (IIM) demonstrate characteristic clinical phenotypes depending on the myositis-specific antibody (MSAs) present. We aimed to identify common or MSA-specific immunological pathways in different immune cell types...
6.
Consecutive BNT162b2 mRNA vaccination induces short-term epigenetic memory in innate immune cells
Yamaguchi Y, Kato Y, Edahiro R, Sondergaard J, Murakami T, Amiya S, et al.
JCI Insight . 2022 Oct; 7(22). PMID: 36282593
Consecutive mRNA vaccinations against SARS-CoV-2 reinforced both innate and adaptive immune responses. However, it remains unclear whether the enhanced innate immune responses are mediated by epigenetic regulation and, if so,...
7.
Distinct transcriptome architectures underlying lupus establishment and exacerbation
Nakano M, Ota M, Takeshima Y, Iwasaki Y, Hatano H, Nagafuchi Y, et al.
Cell . 2022 Aug; 185(18):3375-3389.e21. PMID: 35998627
Systemic lupus erythematosus (SLE) is a complex autoimmune disease involving multiple immune cells. To elucidate SLE pathogenesis, it is essential to understand the dysregulated gene expression pattern linked to various...
8.
Transcriptome analysis of immune cells from Behçet's syndrome patients: the importance of IL-17-producing cells and antigen-presenting cells in the pathogenesis of Behçet's syndrome
Okubo M, Sumitomo S, Tsuchida Y, Nagafuchi Y, Takeshima Y, Yanaoka H, et al.
Arthritis Res Ther . 2022 Aug; 24(1):186. PMID: 35941595
Background: Behçet's syndrome (BS) is an immune-mediated disease characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin symptoms. HLA-B51, as well as other genetic polymorphisms, has been reported to...
9.
Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma
Yasumizu Y, Ohkura N, Murata H, Kinoshita M, Funaki S, Nojima S, et al.
Nat Commun . 2022 Jul; 13(1):4230. PMID: 35869073
Myasthenia gravis (MG) is a neurological disease caused by autoantibodies against neuromuscular-associated proteins. While MG frequently develops in thymoma patients, the etiologic factors for MG are not well understood. Here,...
10.
Combined plasma metabolomic and transcriptomic analysis identify histidine as a biomarker and potential contributor in SLE pathogenesis
Iwasaki Y, Takeshima Y, Nakano M, Okubo M, Ota M, Suzuki A, et al.
Rheumatology (Oxford) . 2022 Jun; 62(2):905-913. PMID: 35689621
Objectives: To investigate metabolite alterations in the plasma of SLE patients to identify novel biomarkers and provide insight into SLE pathogenesis. Methods: Patients with SLE (n = 41, discovery cohort...