Yusuke Aota
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Explore the profile of Yusuke Aota including associated specialties, affiliations and a list of published articles.
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9
Citations
63
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Recent Articles
1.
Maeda Y, Hamada S, Aota Y, Otsubo K, Kano T, Maruoka K
J Org Chem
. 2022 Jan;
87(5):3652-3660.
PMID: 35075904
Chiral sulfoximines have recently been considered as promising bioisosteres in medicinal chemistry. However, methods for preparing chiral sulfoximines in a stereoselective manner are underdeveloped. Herein, we demonstrate an asymmetric synthesis...
2.
Mochimatsu T, Aota Y, Kano T, Maruoka K
Chem Asian J
. 2020 Oct;
15(22):3816-3819.
PMID: 33025747
α-Functionalization of ketones in an umpolung fashion can be achieved by nucleophilic addition to the oxy-allyl cation intermediate. However, applicable carbon nucleophiles are limited to ones with high nucleophilicity. Additionally,...
3.
Aota Y, Kano T, Maruoka K
J Am Chem Soc
. 2019 Nov;
141(49):19263-19268.
PMID: 31739663
Optically active sulfoximines are a promising substance in medicinal chemistry. However, a methodology for preparing chiral sulfoximines in a stereoselective manner has been underdeveloped. Here, we report an asymmetric synthesis...
4.
Aota Y, Maeda Y, Kano T, Maruoka K
Chemistry
. 2019 Oct;
25(69):15755-15758.
PMID: 31573124
Cyclic sulfoximines were readily synthesized by the cyclization of N-propargylsulfinamides without using expensive and toxic metal catalysts. This cyclization proceeded without loss of optical purity of chiral sulfinamides through the...
5.
Aota Y, Kano T, Maruoka K
Angew Chem Int Ed Engl
. 2019 Oct;
58(49):17661-17665.
PMID: 31568618
Innovation in drug discovery critically depends on the development of new bioisosteric groups. Chiral sulfoximines, which contain a tetrasubstituted sulfur atom that bears one nitrogen, one oxygen, and two different...
6.
Chen Z, Aota Y, Nguyen H, Dong V
Angew Chem Int Ed Engl
. 2019 Feb;
58(14):4705-4709.
PMID: 30740841
We report a dynamic kinetic resolution (DKR) of chiral 4-pentenals by olefin hydroacylation. A primary amine racemizes the aldehyde substrate via enamine formation and hydrolysis. Then, a cationic rhodium catalyst...
7.
Miura K, Morishita Y, Matsuno H, Aota Y, Ito H, Tai A
Molecules
. 2017 Dec;
22(12).
PMID: 29231858
2--α-d-Glucopyranosyl-l-ascorbic acid (AA-2G) is one of the stable ascorbic acid (AA) derivatives known as provitamin C agents. We have previously synthesized two types of monoacylated derivatives of AA-2G, 6--acyl-2--α-d-glucopyranosyl-l-ascorbic acids...
8.
Kano T, Aota Y, Maruoka K
Angew Chem Int Ed Engl
. 2017 Nov;
56(51):16293-16296.
PMID: 29110376
A highly stereoselective synthesis of hitherto less accessible chiral α-tertiary amines with multiple structurally similar linear carbon chains was achieved through chiral auxiliary mediated addition of organolithium reagents to the...
9.
Kano T, Aota Y, Asakawa D, Maruoka K
Chem Commun (Camb)
. 2015 Sep;
51(92):16472-4.
PMID: 26412495
In the presence of a Brønsted acid catalyst, both aldehydes and N-Boc-aminals were converted to enecarbamates and N-Boc-iminium salts as activated nucleophiles and electrophiles, respectively, giving unprecedented Mannich adducts. The...