Yukio Okano
Overview
Explore the profile of Yukio Okano including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
1001
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Recent Articles
1.
Sato K, Kimura M, Sugiyama K, Nishikawa M, Okano Y, Nagaoka H, et al.
J Biol Chem
. 2016 Oct;
291(48):25227-25238.
PMID: 27765816
PLEKHG2/FLJ00018 is a Gβγ-dependent guanine nucleotide exchange factor for the small GTPases Rac and Cdc42 and has been shown to mediate the signaling pathways leading to actin cytoskeleton reorganization. Here...
2.
Sato K, Handa H, Kimura M, Okano Y, Nagaoka H, Nagase T, et al.
Cell Signal
. 2012 Sep;
25(1):41-9.
PMID: 23000341
FLJ00018/PLEKHG2 is a guanine nucleotide exchange factor for the Rho family small GTPases. FLJ00018 is directly activated by heterotrimeric G protein Gβγ subunits. Using two-hybrid screening, we have identified non-muscle...
3.
Kozawa S, Honda A, Kajiwara N, Takemoto Y, Nagase T, Nikami H, et al.
Mol Med Rep
. 2011 Aug;
4(6):1157-62.
PMID: 21850377
Peroxisomes catalyze a range of essential metabolic functions, mainly related to lipid metabolism. However, their roles in obesity have yet to be clarified. The aim of this study was to...
4.
Matsushima-Nishiwaki R, Adachi S, Yoshioka T, Yasuda E, Yamagishi Y, Matsuura J, et al.
J Cell Biochem
. 2011 Jul;
112(11):3430-9.
PMID: 21769911
Heat shock protein (HSP) 20, one of the low-molecular weight HSPs, is known to have versatile functions, such as vasorelaxation. However, its precise role in cancer proliferation remains to be...
5.
Nakashima M, Adachi S, Yasuda I, Yamauchi T, Kawaguchi J, Hanamatsu T, et al.
Mol Cancer
. 2011 Jul;
10:79.
PMID: 21722395
Background: Rho-associated coiled-coil containing protein kinase (Rho-kinase/ROCK) is involved in various cellular functions including cell proliferation, and is generally considered to be oncogenic, while some studies show that ROCK functions...
6.
Yamauchi T, Adachi S, Yasuda I, Nakashima M, Kawaguchi J, Nishii Y, et al.
Radiat Res
. 2011 Jun;
176(5):565-74.
PMID: 21692654
Epidermal growth factor receptor (EGFR) is overexpressed in human pancreatic cancer and is one of the clinical targets in its treatment. In the present study we investigated the mechanism underlying...
7.
Adachi S, Yasuda I, Nakashima M, Yamauchi T, Kawaguchi J, Shimizu M, et al.
J Biol Chem
. 2011 Jun;
286(29):26178-87.
PMID: 21646361
Receptor down-regulation is the most prominent regulatory system of EGF receptor (EGFR) signal attenuation and a critical target for therapy against colon cancer, which is highly dependent on the function...
8.
Yoshioka T, Kimura M, Saio M, Era S, Okano Y
Biochem Biophys Res Commun
. 2011 Jun;
410(1):57-61.
PMID: 21635870
RNF8 is a nuclear protein having an N-terminal forkhead-associated (FHA) domain and a C-terminal RING-finger (RF) domain. Depletion of RNF8 caused cell growth inhibition and cell cycle arrest at not...
9.
Mori N, Ishikawa C, Senba M, Kimura M, Okano Y
Biochem Pharmacol
. 2011 Mar;
81(9):1106-15.
PMID: 21371446
We studied the effects of AZD1152, an Aurora B kinase inhibitor, on Burkitt's lymphoma (BL) and Hodgkin's lymphoma (HL) in human tissues and cell cultures and in a murine xenograft...
10.
Matsunami M, Yoshioka T, Minoura T, Okano Y, Muto Y
Biochem Genet
. 2011 Jan;
49(7-8):458-73.
PMID: 21274613
Human PRTB encodes a proline-rich protein of 168 amino acids (PRTB). We analyzed the evolutionary patterns of PRTB from various vertebrate species. Maximum likelihood analyses indicated that while mammalian PRTB...