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Yuki Kishimoto

Explore the profile of Yuki Kishimoto including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 47
Citations 898
Followers 0
Related Specialties
Psychiatry
Biochemistry
Neurology
Top 10 Co-Authors
Seishi Terada
Akihito Ishigami
Naoya Takeda
Osamu Yokota
Hajime Honda
Yosuke Uchitomi
Hidenori Yoshida
Akane Fujii
Shigetoshi Kuroda
Satoshi Obika
Published In
Psychiatry Res
Chemistry
Int Psychogeriatr
Org Biomol Chem
Dement Geriatr Cogn Disord
Affiliations
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Recent Articles
1.
Synthesis and physical and biological properties of 1,3-diaza-2-oxophenoxazine-conjugated oligonucleotides
Yamaji R, Nakagawa O, Kishimoto Y, Fujii A, Matsumura T, Nakayama T, et al.
Bioorg Med Chem . 2022 Sep; 72:116972. PMID: 36057217
The artificial nucleobase 1,3-diaza-2-oxophenoxazine (tC) and its derivative G-clamp strongly bind to guanine and, when incorporated into double-stranded DNA, significantly increase the stability of the latter. As the phenoxazine skeleton...
2.
Four-repeat tauopathies and late-onset psychiatric disorders: Etiological relevance or incidental findings?
Yokota O, Miki T, Ishizu H, Haraguchi T, Kishimoto Y, Takenoshita S, et al.
Neuropathology . 2022 Jul; 43(1):51-71. PMID: 35774036
Argyrophilic grain disease (AGD), progressive supranuclear palsy (PSP) and corticobasal degeneration are four-repeat (4R) tauopathies that develop in the presenium or later. Whether these diseases are associated with the occurrence...
3.
Enhanced duplex- and triplex-forming ability and enzymatic resistance of oligodeoxynucleotides modified by a tricyclic thymine derivative
Kishimoto Y, Fujii A, Nakagawa O, Obika S
Org Biomol Chem . 2021 Sep; 19(37):8063-8074. PMID: 34494641
We designed and synthesized an artificial nucleic acid, [3-(1,2-dihydro-2-oxobenzo[][1,8]naphthyridine)]-2'-deoxy-D-ribofuranose (OBN), with a tricyclic structure in a nucleobase as a thymidine analog. Oligodeoxynucleotides (ODNs) containing consecutive OBN displayed improved duplex-forming ability...
4.
A novel tissue specific alternative splicing variant mitigates phenotypes in Ets2 frame-shift mutant models
Kishimoto Y, Nishiura I, Hirata W, Yuri S, Yamamoto N, Ikawa M, et al.
Sci Rep . 2021 Apr; 11(1):8297. PMID: 33859300
E26 avian leukemia oncogene 2, 3' domain (Ets2) has been implicated in various biological processes. An Ets2 mutant model (Ets2), which lacks the DNA-binding domain, was previously reported to exhibit...
5.
2',4'-BNA/LNA with 9-(2-Aminoethoxy)-1,3-diaza-2-oxophenoxazine Efficiently Forms Duplexes and Has Enhanced Enzymatic Resistance*
Kishimoto Y, Nakagawa O, Fujii A, Yoshioka K, Nagata T, Yokota T, et al.
Chemistry . 2020 Dec; 27(7):2427-2438. PMID: 33280173
Artificial nucleic acids are widely used in various technologies, such as nucleic acid therapeutics and DNA nanotechnologies requiring excellent duplex-forming abilities and enhanced nuclease resistance. 2'-O,4'-C-Methylene-bridged nucleic acid/locked nucleic acid...
6.
Crystallographic Structure of Novel Types of Ag -Mediated Base Pairs in Non-canonical DNA Duplex Containing 2'-O,4'-C-Methylene Bridged Nucleic Acids
Nakagawa O, Aoyama H, Fujii A, Kishimoto Y, Obika S
Chemistry . 2020 Dec; 27(11):3842-3848. PMID: 33274789
Metal-mediated base pairs have widespread applications, such as in DNA-metal nanodevices and sensors. Here, we focused on their sugar conformation in duplexes and observed the crystallographic structure of the non-canonical...
7.
Acute administration of methylphenidate differentially affects cortical processing of emotional facial expressions in attention-deficit hyperactivity disorder children as studied by functional near-infrared spectroscopy
Kobayashi M, Ikeda T, Tokuda T, Monden Y, Nagashima M, Mizushima S, et al.
Neurophotonics . 2020 May; 7(2):025003. PMID: 32377545
It has been reported that children with attention-deficit hyperactivity disorder (ADHD) have impairment in the recognition of angry but not of happy facial expressions, and they show atypical cortical activation...
8.
A mitochondrial uncoupler prodrug protects dopaminergic neurons and improves functional outcome in a mouse model of Parkinson's disease
Kishimoto Y, Johnson J, Fang W, Halpern J, Marosi K, Liu D, et al.
Neurobiol Aging . 2019 Nov; 85:123-130. PMID: 31718928
Dopaminergic neuronal cell loss in the substantia nigra is responsible for the motor symptoms that are the clinical hallmark of Parkinson's disease (PD). As of yet there are no treatments...
9.
Oligonucleotides Containing Phenoxazine Artificial Nucleobases: Triplex-Forming Abilities and Fluorescence Properties
Fujii A, Nakagawa O, Kishimoto Y, Nakatsuji Y, Nozaki N, Obika S
Chembiochem . 2019 Oct; 21(6):860-864. PMID: 31568630
1,3-Diaza-2-oxophenoxazine ("phenoxazine"), a tricyclic cytosine analogue, can strongly bind to guanine moieties and improve π-π stacking effects with adjacent bases in a duplex. Phenoxazine has been widely used for improving...
10.
Chronic Mild Gut Inflammation Accelerates Brain Neuropathology and Motor Dysfunction in α-Synuclein Mutant Mice
Kishimoto Y, Zhu W, Hosoda W, Sen J, Mattson M
Neuromolecular Med . 2019 May; 21(3):239-249. PMID: 31079293
Emerging findings suggest that Parkinson's disease (PD) pathology (α-synuclein accumulation) and neuronal dysfunction may occur first in peripheral neurons of the autonomic nervous system including the enteric branches of the...