Yuichi Nakahara
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Explore the profile of Yuichi Nakahara including associated specialties, affiliations and a list of published articles.
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30
Citations
565
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Recent Articles
1.
Matsuda Y, Shikida N, Hatada N, Yamada K, Seki T, Nakahara Y, et al.
Org Lett
. 2024 Apr;
26(27):5597-5601.
PMID: 38639400
A traceless site-selective conjugation method, "AJICAP-M", was developed for native antibodies at sites using Fc-affinity peptides, focusing on Lys248 or Lys288. It produces antibody-drug conjugates (ADCs) with consistent drug-to-antibody ratios,...
2.
Nakahara Y, Kawaguchi T, Matsuda Y, Endo Y, Date M, Takahashi K, et al.
Langmuir
. 2024 Apr;
40(16):8483-8492.
PMID: 38618876
Recombinant protein production is an essential aspect of biopharmaceutical manufacturing, with serving as a primary host organism. Protein refolding is vital for protein production; however, conventional refolding methods face challenges...
3.
Cornette R, Indo H, Iwata K, Hagiwara-Komoda Y, Nakahara Y, Gusev O, et al.
Mitochondrion
. 2023 Nov;
73:84-94.
PMID: 37956777
The sleeping chironomid (Polypedilum vanderplanki) is the only insect capable of surviving complete desiccation in an ametabolic state called anhydrobiosis. Here, we focused on the role of oxidative stress and...
4.
Nakahara Y, Endo Y, Inoue I
Methods Mol Biol
. 2023 Jun;
2671:335-347.
PMID: 37308654
Ferritin is one of the most promising drug delivery system (DDS) carriers because of its uniform nanosize, biodistribution, efficient cellular uptake, and biocompatibility. Conventionally, a disassembly/reassembly method that requires pH...
5.
Watanabe M, Bhawal U, Takemoto S, Nishiyama N, Nakahara Y, Tatematsu K, et al.
Biotechnol Bioeng
. 2021 Apr;
118(7):2585-2596.
PMID: 33818762
Silk fibroin (SF) from Bombyx mori has superior properties as both a textile and a biomaterial, and has been used to functionalize the surfaces of various medical inorganic materials including...
6.
Inoue I, Chiba M, Ito K, Okamatsu Y, Suga Y, Kitahara Y, et al.
Nanoscale
. 2021 Jan;
13(3):1875-1883.
PMID: 33439183
Conventionally, a disassembly and reassembly method has been used for encapsulation of drug molecules in ferritin protein nano-cages. However, clinical applications of ferritin have been greatly restricted by its limited...
7.
Cornette R, Gusev O, Nakahara Y, Shimura S, Kikawada T, Okuda T
Zoolog Sci
. 2015 May;
32(3):248-54.
PMID: 26003979
Chironomid midges (Diptera; Chironomidae) are found in various environments from the high Arctic to the Antarctic, including temperate and tropical regions. In many freshwater habitats, members of this family are...
8.
Horikawa D, Yamaguchi A, Sakashita T, Tanaka D, Hamada N, Yukuhiro F, et al.
Astrobiology
. 2012 Apr;
12(4):283-9.
PMID: 22490117
Tardigrades are tiny (less than 1 mm in length) invertebrate animals that have the potential to survive travel to other planets because of their tolerance to extreme environmental conditions by...
9.
Gusev O, Nakahara Y, Vanyagina V, Malutina L, Cornette R, Sakashita T, et al.
PLoS One
. 2010 Nov;
5(11):e14008.
PMID: 21103355
Anhydrobiotic chironomid larvae can withstand prolonged complete desiccation as well as other external stresses including ionizing radiation. To understand the cross-tolerance mechanism, we have analyzed the structural changes in the...
10.
Cornette R, Kanamori Y, Watanabe M, Nakahara Y, Gusev O, Mitsumasu K, et al.
J Biol Chem
. 2010 Sep;
285(46):35889-99.
PMID: 20833722
Some organisms are able to survive the loss of almost all their body water content, entering a latent state known as anhydrobiosis. The sleeping chironomid (Polypedilum vanderplanki) lives in the...