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Yuichi Kamikubo

Explore the profile of Yuichi Kamikubo including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 181
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Recent Articles
1.
Kamikubo Y, Nagaya S, Inoue R, Yamaguchi K, Morimoto-Kamata R, Morishita E, et al.
Thromb Haemost . 2025 Mar; PMID: 40049601
Background And Objectives: Initial thrombin (FIIa) generated via the tissue factor (TF) pathway plays a crucial role in amplifying coagulation. There is growing evidence that the TF pathway might contribute...
2.
Ohkura N, Morimoto-Kamata R, Kamikubo Y, Takahashi Y, Oishi K
Drug Discov Ther . 2023 Oct; 17(5):346-350. PMID: 37839864
Obesity and diabetes mellitus are associated with increased risk of arterial thrombosis and venous thromboembolism. Tsumura Suzuki Obese Diabetes (TSOD) mice are useful models for elucidating the molecular mechanisms of...
3.
Kanaji S, Orje J, Kanaji T, Kamikubo Y, Morodomi Y, Chen Y, et al.
Blood Adv . 2018 Oct; 2(19):2522-2532. PMID: 30287479
The interaction of platelet glycoprotein Ibα (GPIbα) with von Willebrand factor (VWF) initiates hemostasis after vascular injury and also contributes to pathological thrombosis. GPIbα binding to the VWF A1 domain...
4.
Kamikubo Y, Mendolicchio G, Zampolli A, Marchese P, Rothmeier A, Orje J, et al.
Blood . 2017 Jul; 130(14):1661-1670. PMID: 28729433
Safe and effective antithrombotic therapy requires understanding of mechanisms that contribute to pathological thrombosis but have a lesser impact on hemostasis. We found that the extrinsic tissue factor (TF) coagulation...
5.
Rothmeier A, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, et al.
Arterioscler Thromb Vasc Biol . 2017 May; 37(7):1323-1331. PMID: 28495929
Objective: Coagulation initiation by tissue factor (TF) is regulated by cellular inhibitors, cell surface availability of procoagulant phosphatidylserine, and thiol-disulfide exchange. How these mechanisms contribute to keeping TF in a...
6.
Kamikubo Y, Neels J, Degryse B
Int J Biochem Cell Biol . 2008 Aug; 41(3):578-85. PMID: 18703159
We have previously reported that the serpin plasminogen activator inhibitor-1 activates the Janus kinase (Jak)/signal transducer and activator of transcription (Stat) signalling pathway and stimulates cell migration by binding to...
7.
Komissarov A, Andreasen P, Declerck P, Kamikubo Y, Zhou A, Gruber A
Thromb Res . 2007 Nov; 122(3):397-404. PMID: 18045665
Background: Activated protein C (APC) reduces mortality in severe sepsis. Protecting APC in the circulatory system from inactivation by serine protease inhibitors (serpins) could improve its therapeutic efficiency. Significantly elevated...
8.
Kamikubo Y, Dellas C, Loskutoff D, Quigley J, Ruggeri Z
Biochem J . 2007 Nov; 410(3):595-604. PMID: 17983356
The extracellular domain of the human leptin receptor (Ob-R) contains 20 potential N-glycosylation sites whose role in leptin binding remains to be elucidated. We found that a mammalian cell-expressed sOb-R...
9.
Kamikubo Y, Kroon G, Curriden S, Dyson H, Loskutoff D
Biochemistry . 2006 Mar; 45(10):3297-306. PMID: 16519524
The high-affinity binding site in human vitronectin (VN) for plasminogen activator inhibitor-1 (PAI-1) has been localized to the NH(2)-terminal cysteine-rich somatomedin B (SMB) domain (residues 1-44). A number of published...
10.
Tomokiyo K, Kamikubo Y, Hanada T, Araki T, Nakatomi Y, Ogata Y, et al.
Blood . 2004 Oct; 105(3):1078-84. PMID: 15459008
Plasma von Willebrand factor (VWF) has been identified as an indispensable factor for platelet adhesion and thrombus formation on a collagen surface under flow conditions. VWF binds to collagen and...