Andras Gruber
Overview
Explore the profile of Andras Gruber including associated specialties, affiliations and a list of published articles.
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83
Citations
2444
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Recent Articles
1.
Verbout N, Lorentz C, Markway B, Wallisch M, Marbury T, Di Cera E, et al.
Commun Med (Lond)
. 2024 Jul;
4(1):153.
PMID: 39060370
Background: The protein C system regulates blood coagulation, inflammation, and vascular integrity. AB002 is an injectable protein C activating enzyme under investigation to safely prevent and treat thrombosis. In preclinical...
2.
Jung J, Gruber A, Heseltine P, Rajamani K, Ameriso S, Fisher M
J Clin Neurol
. 2024 Feb;
20(2):140-152.
PMID: 38330416
The relationship between infections and stroke has not been fully characterized, probably delaying the development of specific treatments. This narrative review addresses mechanisms of stroke linked to infections, including hypercoagulability,...
3.
Gailani D, Gruber A
Blood
. 2023 Dec;
143(15):1465-1475.
PMID: 38142404
Direct oral anticoagulants (DOACs) that inhibit the coagulation proteases thrombin or factor Xa (FXa) have replaced warfarin and other vitamin K antagonists (VKAs) for most indications requiring long-term anticoagulation. In...
4.
Sparkenbaugh E, Henderson M, Miller-Awe M, Abrams C, Ilich A, Trebak F, et al.
Blood
. 2023 Jan;
141(15):1871-1883.
PMID: 36706361
A hypercoagulable state, chronic inflammation, and increased risk of venous thrombosis and stroke are prominent features in patients with sickle cell disease (SCD). Coagulation factor XII (FXII) triggers activation of...
5.
Wan J, Tanratana P, Roest M, Gruber A, Pawlinski R, Wolberg A, et al.
Blood Adv
. 2022 Dec;
7(9):1915-1925.
PMID: 36583671
Thrombin generation (TG) assays serve as a valuable tool to study the amplifying roles of intrinsic pathway factors in human coagulation and provide functional insights into the increased bleeding observed...
6.
Morla S, Deguchi H, Zilberman-Rudenko J, Gruber A, McCarty O, Srivastava P, et al.
J Biol Chem
. 2022 Jan;
298(2):101567.
PMID: 35007530
Skeletal muscle myosin (SkM) has been shown to possess procoagulant activity; however, the mechanisms of this coagulation-enhancing activity involving plasma coagulation pathways and factors are incompletely understood. Here, we discovered...
7.
Lorentz C, Tucker E, Verbout N, Shatzel J, Olson S, Markway B, et al.
Blood
. 2021 Jun;
138(22):2173-2184.
PMID: 34086880
End-stage renal disease (ESRD) patients on chronic hemodialysis have repeated blood exposure to artificial surfaces that can trigger clot formation within the hemodialysis circuit. Dialyzer clotting can lead to anemia...
8.
Puy C, Pang J, Reitsma S, Lorentz C, Tucker E, Gailani D, et al.
J Immunol
. 2021 Apr;
206(8):1784-1792.
PMID: 33811105
Complement factor H (CFH) is the major inhibitor of the alternative pathway of the complement system and is structurally related to beta2-glycoprotein I, which itself is known to bind to...
9.
Silasi R, Keshari R, Regmi G, Lupu C, Georgescu C, Simmons J, et al.
Blood
. 2021 Feb;
138(2):178-189.
PMID: 33598692
Activation of coagulation factor (F) XI promotes multiorgan failure in rodent models of sepsis and in a baboon model of lethal systemic inflammation induced by infusion of heat-inactivated Staphylococcus aureus....
10.
Reitsma S, Pang J, Raghunathan V, Shatzel J, Lorentz C, Tucker E, et al.
Am J Physiol Cell Physiol
. 2021 Jan;
320(3):C365-C374.
PMID: 33471623
Factor XI (FXI) has been shown to bind platelets, but the functional significance of this observation remains unknown. Platelets are essential for hemostasis and play a critical role in thrombosis,...