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Yuen Rong M Sim

Explore the profile of Yuen Rong M Sim including associated specialties, affiliations and a list of published articles. Areas
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Articles 3
Citations 25
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Recent Articles
1.
Yap J, Yuan J, Ng W, Chen G, Sim Y, Goh K, et al.
Mol Cancer . 2023 Aug; 22(1):125. PMID: 37543582
Hairy cell leukemia (HCL) is a B-lymphoma induced by BRAF(V600E) mutation. However, introducing BRAF(V600E) in B-lymphocytes fails to induce hematological malignancy, suggesting that BRAF(V600E) needs concurrent mutations to drive HCL...
2.
Degirmenci U, Yap J, Sim Y, Qin S, Hu J
Cancer Drug Resist . 2022 May; 4(3):665-683. PMID: 35582307
Hyperactive RAS/RAF/MEK/ERK signaling has a well-defined role in cancer biology. Targeting this pathway results in complete or partial regression of most cancers. In recent years, cancer genomic studies have revealed...
3.
Yap J, Deepak R, Tian Z, Ng W, Goh K, Foo A, et al.
Sci Adv . 2021 Jun; 7(24). PMID: 34108213
Although targeting BRAF mutants with RAF inhibitors has achieved promising outcomes in cancer therapy, drug resistance remains a remarkable challenge, and underlying molecular mechanisms are not fully understood. Here, we...