Yudan Fan
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Explore the profile of Yudan Fan including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
33
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Recent Articles
1.
An P, Fan Y, Wang Q, Huang N, Chen H, Sun J, et al.
Biochem Biophys Res Commun
. 2024 Oct;
735:150825.
PMID: 39426134
Obstruction of bile ducts due to gallstones can lead to biliary acute pancreatitis (BAP). According to Perides et al., G protein-coupled bile acid receptor-1 (GPBAR1) mediates BAP. However, Zi's findings...
2.
Wang X, Fan Y, Wu Q
Front Cell Dev Biol
. 2023 Mar;
11:1145611.
PMID: 36875763
Transcription elongation is a fundamental molecular process which is accurately regulated to ensure proper gene expression in cellular activities whereas its malfunction is associated with impaired cellular functions. Embryonic stem...
3.
Zhou R, Bu W, Fan Y, Du Z, Zhang J, Zhang S, et al.
Medicina (Kaunas)
. 2023 Feb;
59(2).
PMID: 36837523
: Most published research has only investigated a single timepoint after the onset of severe acute pancreatitis (SAP), meaning that they have been unable to observe the relationship between the...
4.
Song T, Wang P, Yu X, Wang A, Chai G, Fan Y, et al.
Br J Pharmacol
. 2018 Dec;
176(3):491-504.
PMID: 30500985
Background And Purpose: The biological significance of the multi-site phosphorylation of Bcl-2 at its loop region (T69, S70 and S87) has remained controversial for decades. This is a major obstacle...
5.
Song T, Zhang M, Liu P, Xue Z, Fan Y, Zhang Z
Biochem Pharmacol
. 2018 Jun;
155:102-109.
PMID: 29953843
Targeting Bcl-2 with ABT-199 (Venetoclax) shows limited single-agent activity against many cancers in both preclinical and clinical investigations. Combination therapies have attracted great attention. The principal purpose of this study...
6.
Wang Z, Xu W, Song T, Guo Z, Liu L, Fan Y, et al.
Arch Pharm (Weinheim)
. 2016 Dec;
350(1).
PMID: 27911011
Based on a known selective Mcl-1 inhibitor, 6-chloro-3-(3-(4-chloro-3,5-dimethylphenoxy)propyl)-1H-indole-2-carboxylic acid, we applied a fragment-based approach to obtain new molecules that extended into the p1 pocket of the BH3 groove and then...
7.
Song T, Wang Z, Ji F, Feng Y, Fan Y, Chai G, et al.
Angew Chem Int Ed Engl
. 2016 Oct;
55(46):14250-14256.
PMID: 27701804
By means of limited proteolysis assay, three-dimensional NMR, X-ray crystallography and alanine mutations, a dynamic region at the Q221R222N223 motif in the Bcl-2 homology 3 (BH3) domain of Mcl-1 has...
8.
Wang Z, Song T, Feng Y, Guo Z, Fan Y, Xu W, et al.
J Med Chem
. 2016 Mar;
59(7):3152-62.
PMID: 26982372
No α-helical mimetic that exhibits Bcl-2/MDM2 dual inhibition has been rationally designed due to the different helicities of the α-helixes at their binding interfaces. Herein, we extracted a one-turn α-helix-mimicking...
9.
Wang A, Song T, Wang Z, Liu Y, Fan Y, Zhang Y, et al.
Chem Biol Drug Des
. 2015 Nov;
87(4):551-61.
PMID: 26518611
Inhibition of interactions between Mcl-1 and proapoptotic proteins is considered to be a therapeutic strategy to induce apoptosis in cancer cells. Here, we adopted molecular dynamics simulation with molecular mechanics-Poisson...