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Yu-Zhang He

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Recent Articles
1.
Li G, Long T, Zhou S, Xia L, Gao A, Wan L, et al.
Drug Resist Updat . 2024 Aug; 77:101142. PMID: 39214042
The spread of antibiotic resistance genes (ARGs), particularly those carried on plasmids, poses a major risk to global health. However, the extent and frequency of ARGs transfer in microbial communities...
2.
He Y, Kuang X, Long T, Li G, Ren H, He B, et al.
J Antimicrob Chemother . 2021 Oct; 77(1):74-82. PMID: 34613377
Objectives: In this study, we developed an IS26-based CRISPR/Cas9 system as a proof-of-concept study to explore the potential of a re-engineered bacterial translocatable unit (TU) for curing and immunizing against...
3.
He Y, Yan J, He B, Ren H, Kuang X, Long T, et al.
Antimicrob Agents Chemother . 2021 Aug; 65(10):e0105421. PMID: 34339270
The global spread of antimicrobial-resistant bacteria has been one of the most severe threats to public health. The emergence of the gene has posed a considerable threat to antimicrobial medication...
4.
He Y, Xu Y, Sun J, Gao B, Li G, Zhou Y, et al.
Microb Drug Resist . 2021 Jun; 27(12):1624-1632. PMID: 34077284
This study reported the involvement of a gene cluster from a conjugative plasmid in the biofilm formation of . We used a novel EZ-Tn transposon technique to generate a transposon...
5.
He Y, Long T, He B, Li X, Li G, Chen L, et al.
Front Microbiol . 2021 Jan; 11:564973. PMID: 33510713
Objectives: The emergence of mobile colistin resistance genes has compromised the efficacy of the last resort antibiotic, colistin, in clinical treatment. The gene was first identified in Belgium in association...
6.
Chen C, Cui C, Yu J, He Q, Wu X, He Y, et al.
Genome Med . 2020 Dec; 12(1):111. PMID: 33287863
Background: The recent emergence and dissemination of high-level mobile tigecycline resistance Tet(X) challenge the clinical effectiveness of tigecycline, one of the last-resort therapeutic options for complicated infections caused by multidrug-resistant...
7.
He Y, Long T, Chen C, He B, Li X, Schuyler J, et al.
Antimicrob Agents Chemother . 2020 Jul; 64(10). PMID: 32660996
The mobile colistin resistance gene has globally disseminated since it was first reported in 2017 in mobilization assays in this study demonstrate the functionality of the composite transposon structure IS-IS...
8.
He Y, Li X, Miao Y, Lin J, Sun R, Wang X, et al.
Front Microbiol . 2019 Feb; 10:15. PMID: 30723461
The mobile colistin resistance gene is a serious threat to global human and animal health. The composite transposon Tn and its circular intermediate were proposed to be involved in the...
9.
Sun J, Li X, Fang L, Sun R, He Y, Lin J, et al.
Int J Antimicrob Agents . 2018 Jan; 51(6):842-847. PMID: 29371103
Two colistin-resistant Escherichia coli strains (FS13Z2S and FS3Z6C) possessing chromosomally encoded mcr-1 isolated from swine were characterised. Whole-genome sequencing revealed that in strain FS13Z2S mcr-1 occurred in triplicate in the...
10.
Zhou Y, Tao M, He Y, Sun J, Liu Y, Liao X
Antimicrob Agents Chemother . 2017 Oct; 62(1). PMID: 29038275
Antimicrobial resistance among uropathogens has increased the rates of infection-related morbidity and mortality. Antofloxacin is a novel fluoroquinolone with broad-spectrum antibacterial activity against urinary Gram-negative bacilli, such as This study...