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Yu-Tsung Shih

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Articles 15
Citations 291
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Recent Articles
1.
Jiang M, Ding H, Huang Y, Lau C, Guo Y, Luo J, et al.
Circ Res . 2025 Mar; PMID: 40071330
Background: Atherosclerosis is characterized by the accumulation of fatty and fibrotic plaques, which preferentially develop at curvatures and branches along the arterial trees that are exposed to disturbed flow. However,...
2.
Wang T, Hou W, Hsiao B, Lo T, Chen Y, Yang C, et al.
Br J Pharmacol . 2025 Mar; PMID: 40038554
Background And Purpose: In diabetes (DM), elevated blood sugar levels contribute to the overproduction of reactive oxygen species (ROS), leading to endothelial progenitor cell (EPC) dysfunction. This study aimed to...
3.
Shih Y, Cheng K, Ko Y, Lin C, Wang M, Lee C, et al.
Biomaterials . 2024 May; 309:122600. PMID: 38718614
Engineering vascularized tissues remains a promising approach for treating ischemic cardiovascular diseases. The availability of 3D-bioprinted vascular grafts that induce therapeutic angiogenesis can help avoid necrosis and excision of ischemic...
4.
Wei S, Fu W, Liu C, Wang W, Shih Y, Chien S, et al.
Proc Natl Acad Sci U S A . 2024 Jan; 121(5):e2318718121. PMID: 38252820
Several compounds have been used for atherosclerosis treatment, including clinical trials; however, no anti-atherosclerotic drugs based on hemodynamic force-mediated atherogenesis have been discovered. Our previous studies demonstrated that "small mothers...
5.
Cheng C, Lin X, Pu Y, Tse J, Wang Y, Zhang C, et al.
J Adv Res . 2022 Dec; 43:187-203. PMID: 36585108
Introduction: Atherosclerotic complications represent the leading cause of cardiovascular mortality globally. Dysfunction of endothelial cells (ECs) often initiates the pathological events in atherosclerosis. Objectives: In this study, we sought to...
6.
Shih Y, Wei S, Chen J, Wang W, Wu H, Wang M, et al.
Eur Heart J . 2022 Nov; 44(4):304-318. PMID: 36380599
Background And Aims: Atherosclerosis preferentially develops in arterial branches and curvatures where vascular endothelium is exposed to disturbed flow. In this study, the effects of disturbed flow on the regulation...
7.
Wei S, Shih Y, Wu H, Wang W, Lee P, Lee C, et al.
Circ Res . 2021 Nov; 129(12):1158-1174. PMID: 34747636
Rationale: Disturbed flow occurring in arterial branches and curvatures induces vascular endothelial cell (EC) dysfunction and atherosclerosis. We postulated that disturbed flow plays important role in modulating phosphoprotein expression profiles...
8.
Wang W, Chen L, Wei S, Shih Y, Huang Y, Lee P, et al.
Front Cell Dev Biol . 2021 May; 9:647714. PMID: 33959608
MicroRNAs (miRs) and bone morphogenetic protein receptor-specific Smads are mechano-responsive molecules that play vital roles in modulating endothelial cell (EC) functions in response to blood flow. However, the roles of...
9.
Lee D, Yang T, Huang Y, Lee C, Chen L, Shih Y, et al.
Atherosclerosis . 2018 Feb; 271:36-44. PMID: 29459264
Background And Aims: MicroRNA (miR)-10a is a shear-regulated miR with the lowest expression in vascular endothelial cells (ECs) in athero-susceptible regions with oscillatory shear stress (OS). The aim of this...
10.
Lee D, Lin T, Lee C, Zhou J, Huang Y, Lee P, et al.
Proc Natl Acad Sci U S A . 2017 Feb; 114(8):2072-2077. PMID: 28167758
Histone deacetylases (HDACs) and microRNAs (miRs) have emerged as two important epigenetic factors in the regulation of vascular physiology. This study aimed to elucidate the relationship between HDACs and miRs...